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CAPN1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245738

Calpain 1 (mu-calpain), a calcium-dependent cysteine C2 endopeptidase, is involved in myofibrillar protein degradation. In skeletal muscles, activation of Calpain I results in degradation of skeletal structural proteins, improving meat tenderness. Calpains I… More details

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Product Overview

Product Name
CAPN1 / Calpain 1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 15C10] (IgG1)
Product Gene Name
anti-CAPN1 antibody
Product Synonym Names
Anti-CAPN1 / Calpain 1 Antibody (clone 15C10) IHC-plus; CAPN1; Calpain i; Calpain mu-type; Calpain; large polypeptide L1; Calpain-1 catalytic subunit; Calpain 1; Calpain-1 large subunit; CANP; CANP1; Mu CANP; Mu-calpain; Mu-type calpain; MuCANP; Micromolar-calpain; MuCL; CANP 1; CANPL1; CAPN1; Calpain 1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
15C10
Host
Mouse
Species Reactivity
Bovine, Human, Mouse, Rat
Form/Format
0.02M sodium phosphate, pH 7.5, 0.15M sodium chloride, 50% glycerol, 3mM sodium azide. Sourced in TCS.
Purity/Purification
Protein A/G Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
81,890 Da
OMIM
114220
3D Structure
ModBase 3D Structure for P07384
Immunogen Description
Calpain purified from human placenta.
Immunogen Type
Purified protein
Immunogen
CAPN1 / Calpain 1 antibody was raised against calpain purified from human placenta.

Product Categories/Family for anti-CAPN1 antibody

Family: Protease; Subfamily: Cysteine C2
Applications Tested/Suitable for anti-CAPN1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
Application Notes for anti-CAPN1 antibody
ELISA, IHC-P (5 - 10 ug/ml), IP, WB

Immunohistochemistry (IHC) of anti-CAPN1 antibody

Anti-CAPN1 / Calpain 1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CAPN1 Monoclonal Antibody – Cat# MBS245738

Immunohistochemistry (IHC) of anti-CAPN1 antibody

Anti-CAPN1 / Calpain 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CAPN1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245738

Other Notes

Small volumes of anti-CAPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAPN1 purchase

MBS245738 is an antibody targeting CAPN1. Also known as Mouse Monoclonal [clone 15C10] (IgG1). Reactive in Bovine, Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CAPN1. It may not necessarily be applicable to this product.

NCBI GI #
311893363
NCBI GeneID
823
NCBI Accession #
NP_001185797.1
UniProt Primary Accession #
P07384
UniProt Secondary Accession #
Q2TTR0; Q6DHV4
UniProt Related Accession #
P07384
GenBank Nucleotide #
NM_001198868.1
NCBI Official Full Name
calpain-1 catalytic subunit
NCBI Official Synonym Full Names
calpain 1, (mu/I) large subunit
NCBI Official Symbol
CAPN1
NCBI Official Synonym Symbols
CANP; muCL; CANP1; CANPL1; muCANP
UniProt Protein Name
Calpain-1 catalytic subunit
UniProt Synonym Protein Names
Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP
Protein Family
Calpain
UniProt Gene Name
CAPN1
UniProt Synonym Gene Names
CANPL1; CANP 1; muCANP
UniProt Entry Name
CAN1_HUMAN
NCBI Protein Information
calpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein

NCBI Summary for CAPN1

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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UniProt Comments for CAPN1

CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family.

Protein type: Motility/polarity/chemotaxis; EC 3.4.22.52; Protease

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: focal adhesion; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; receptor catabolic process; positive regulation of cell proliferation; proteolysis
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Research Articles on CAPN1

1. Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAPN1 antibody

 Reference Product  PubMed Publications
 CAST antibody  >32 publications with CAPN1 and CAST
 CAPNS1 antibody  >14 publications with CAPN1 and CAPNS1
 PTPN1 antibody  >2 publications with CAPN1 and PTPN1
 TP53 antibody  >1 publications with CAPN1 and TP53

Pathways associated with anti-CAPN1 antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram

Diseases associated with anti-CAPN1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >21 publications with CAPN1 and Death
 Nervous System Diseases Antibodies  >18 publications with CAPN1 and Nervous System Diseases
 Inflammation Antibodies  >5 publications with CAPN1 and Inflammation
 Necrosis Antibodies  >5 publications with CAPN1 and Necrosis
 Nerve Degeneration Antibodies  >4 publications with CAPN1 and Nerve Degeneration
 Heart Diseases Antibodies  >4 publications with CAPN1 and Heart Diseases
 Fibrosis Antibodies  >4 publications with CAPN1 and Fibrosis
 Weight Gain Antibodies  >3 publications with CAPN1 and Weight Gain
 Cardiomyopathies Antibodies  >2 publications with CAPN1 and Cardiomyopathies
 Edema Antibodies  >2 publications with CAPN1 and Edema

Organs/Tissues associated with anti-CAPN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >46 publications with CAPN1 and Muscle
 Blood Antibodies  >18 publications with CAPN1 and Blood
 Brain Antibodies  >13 publications with CAPN1 and Brain
 Nerve Antibodies  >12 publications with CAPN1 and Nerve
 Eye Antibodies  >8 publications with CAPN1 and Eye
 Adipose Tissue Antibodies  >8 publications with CAPN1 and Adipose Tissue
 Connective Tissue Antibodies  >6 publications with CAPN1 and Connective Tissue
 Embryonic Tissue Antibodies  >6 publications with CAPN1 and Embryonic Tissue
 Kidney Antibodies  >6 publications with CAPN1 and Kidney
 Heart Antibodies  >5 publications with CAPN1 and Heart
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