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OAT Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245833

OAT encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme is the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of… More details

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Product Overview

Product Name
OAT, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone AT23A2] (IgG1,k) to Human OAT
Product Gene Name
Product Synonym Names
Anti-OAT Antibody (clone AT23A2) IHC-plus; OAT; GACR; HOGA; OKT; Gyrate atrophy; OATASE; Ornithine aminotransferase; Human OAT
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
AT23A2
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate buffered saline, pH 7.4, 0.1% sodium azide
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human OAT
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
32,853 Da
OMIM
phenotype 613349
3D Structure
ModBase 3D Structure for P04181
Target Species
Human
Immunogen Description
Recombinant human OAT
Immunogen Type
Recombinant protein
Immunogen
OAT antibody was raised against recombinant human OAT
Applications Tested/Suitable for anti-OAT antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-OAT antibody
IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-OAT antibody

Anti-OAT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-OAT Monoclonal Antibody – Cat# MBS245833

Immunohistochemistry (IHC) of anti-OAT antibody

Anti-OAT antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-OAT Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245833

Other Notes

Small volumes of anti-OAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OAT purchase

MBS245833 is an antibody targeting OAT. Also known as Mouse Monoclonal [clone AT23A2] (IgG1,k) to Human OAT. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for OAT. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ornithine aminotransferase, mitochondrial isoform 1
NCBI Official Synonym Full Names
ornithine aminotransferase
NCBI Official Symbol
OAT
NCBI Official Synonym Symbols
OKT; GACR; HOGA; OATASE
UniProt Protein Name
Ornithine aminotransferase, mitochondrial
UniProt Synonym Protein Names
Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferaseCleaved into the following 2 chains:Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form
UniProt Gene Name
OAT
UniProt Entry Name
OAT_HUMAN
NCBI Protein Information
ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine delta-aminotransferase; ornithine-oxo-acid aminotransferase

NCBI Summary for OAT

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]
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UniProt Comments for OAT

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding

Biological Process: visual perception; amino acid biosynthetic process

Disease: Gyrate Atrophy Of Choroid And Retina
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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