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CORO1B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245953

MBS245953 is an antibody targeting CORO1B. Also known as Mouse Monoclonal [clone 1E7] (IgG1,k) to Human CORO1B. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CORO1B, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 1E7] (IgG1,k) to Human CORO1B
Product Gene Name
anti-CORO1B antibody
Product Synonym Names
Anti-CORO1B Antibody (clone 1E7) IHC-plus; CORO1B; Coronin-1B; CORONIN-2; Human CORO1B
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1E7
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.46 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
54,235 Da
OMIM
609849
3D Structure
ModBase 3D Structure for Q9BR76
Target Species
Human
Immunogen Description
CORO1B (AAH06449, 1 a.a. ~ 490 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
CORO1B antibody was raised against cORO1B (AAH06449, 1 a.a. ~ 490 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-CORO1B antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CORO1B antibody
ELISA, IHC-P (5 ug/ml), WB
Usage: Western Blot (Cell lysate) - positive control HeLa NE. Sandwich ELISA (Recombinant protein).

Immunohistochemistry (IHC) of anti-CORO1B antibody

Anti-CORO1B antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CORO1B Monoclonal Antibody – Cat# MBS245953

Immunohistochemistry (IHC) of anti-CORO1B antibody

Anti-CORO1B antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CORO1B Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245953

Immunohistochemistry (IHC) of anti-CORO1B antibody

Anti-CORO1B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CORO1B Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245953

Western Blot (WB) of anti-CORO1B antibody

CORO1B monoclonal antibody, clone 1E7 Western blot of CORO1B expression in HeLa NE.
Mouse Anti-CORO1B Monoclonal Antibody, Western Blot (WB) – Cat# MBS245953

ELISA (EIA) of anti-CORO1B antibody

Detection limit for recombinant GST tagged CORO1B is approximately 0.3 ng/ml as a capture antibody.
Mouse Anti-CORO1B Monoclonal Antibody, ELISA (EIA) – Cat# MBS245953

Other Notes

Small volumes of anti-CORO1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CORO1B. It may not necessarily be applicable to this product.

NCBI GI #
14149734
NCBI GeneID
57175
NCBI Accession #
NP_065174.1
UniProt Primary Accession #
Q9BR76
UniProt Secondary Accession #
B2RD45
UniProt Related Accession #
Q9BR76
GenBank Nucleotide #
NM_020441.2
NCBI Official Full Name
coronin-1B
NCBI Official Synonym Full Names
coronin, actin binding protein, 1B
NCBI Official Symbol
CORO1B
NCBI Official Synonym Symbols
CORONIN-2
UniProt Protein Name
Coronin-1B
UniProt Synonym Protein Names
Coronin-2
Protein Family
Coronin
UniProt Gene Name
CORO1B
UniProt Entry Name
COR1B_HUMAN
NCBI Protein Information
coronin-1B

NCBI Summary for CORO1B

Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

UniProt Comments for CORO1B

coronin 1B: an actin-binding protein that regulates leading edge dynamics and cell motility in fibroblasts. Coordinates the Arp2/3 complex (includes ACTR2, ARPC1B and ARPC2) cofilin activities at the leading edge. Localized to the leading edge in fibroblasts and weakly along actin stress fibers. Phosphorylation by PKC regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Belongs to the WD repeat coronin family.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: focal adhesion; lamellipodium; cytoplasm; leading edge; stress fiber; plasma membrane; actin filament; actin cytoskeleton

Molecular Function: actin filament binding; identical protein binding; protein binding

Biological Process: actin filament bundle formation; cell migration; wound healing; ruffle organization and biogenesis; actin cytoskeleton organization and biogenesis
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Research Articles on CORO1B

1. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-CORO1B antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1 publications with CORO1B and Vascular
 Bone Marrow Antibodies  >1 publications with CORO1B and Bone Marrow
 Bone Antibodies  >1 publications with CORO1B and Bone
 Embryonic Tissue Antibodies  >1 publications with CORO1B and Embryonic Tissue
 Blood Antibodies  >1 publications with CORO1B and Blood
 Stomach Antibodies  >1 publications with CORO1B and Stomach
 Heart Antibodies  >1 publications with CORO1B and Heart
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