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CREG Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246008

MBS246008 is an antibody targeting CREG. Also known as Mouse Monoclonal [clone 1B7] (IgG1,k) to Human CREG / CREG1. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CREG / CREG1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 1B7] (IgG1,k) to Human CREG / CREG1
Product Gene Name
Product Synonym Gene Name
CREG1
Product Synonym Names
Anti-CREG / CREG1 Antibody (clone 1B7) IHC-plus; CREG1; CREG; Protein CREG1; Human CREG; CREG1
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1B7
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.42 mg/ml (lot specific)
Specificity
Human CREG1
Preparation and Storage
Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
24,075 Da
3D Structure
ModBase 3D Structure for O75629
Target Species
Human
Immunogen Description
CREG1 (NP_003842, 121 a.a. ~ 221 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
CREG / CREG1 antibody was raised against cREG1 (NP_003842, 121 a.a. ~ 221 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-CREG antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CREG antibody
ELISA, IHC-P (10 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-CREG antibody

Anti-CREG1 / CREG antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-CREG Monoclonal Antibody – Cat# MBS246008

Western Blot (WB) of anti-CREG antibody

Antibody Western blot of CREG1 expression in HL-60.
Mouse Anti-CREG Monoclonal Antibody, Western Blot (WB) – Cat# MBS246008

ELISA (EIA) of anti-CREG antibody

Detection limit for recombinant GST tagged CREG1 is approximately 0.3 ng/ml as a capture antibody.
Mouse Anti-CREG Monoclonal Antibody, ELISA (EIA) – Cat# MBS246008

Other Notes

Small volumes of anti-CREG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CREG. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein CREG1
NCBI Official Synonym Full Names
cellular repressor of E1A-stimulated genes 1
NCBI Official Symbol
CREG1
NCBI Official Synonym Symbols
CREG
UniProt Protein Name
Protein CREG1
UniProt Synonym Protein Names
Cellular repressor of E1A-stimulated genes 1
UniProt Gene Name
CREG1
UniProt Synonym Gene Names
CREG
UniProt Entry Name
CREG1_HUMAN
NCBI Protein Information
protein CREG1

NCBI Summary for CREG

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
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UniProt Comments for CREG

CREG1: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Belongs to the CREG family.

Protein type: Transcription, coactivator/corepressor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: transcription factor complex

Molecular Function: FMN binding; oxidoreductase activity; transcription factor binding; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; multicellular organismal development; regulation of growth
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CREG antibody

Pathways associated with anti-CREG antibody

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