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MUC2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438360

MBS438360 is an antibody targeting MUC2. Also known as MUC2 (Mucin 2) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MUC2 (Mucin 2), Monoclonal Antibody
Full Product Name
MUC2 (Mucin 2) Mouse Monoclonal Antibody
Product Gene Name
anti-MUC2 antibody
Product Synonym Names
Mucin-2, Intestinal mucin-2, Mucin like protein, (MLP), SMUC
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
CCP58
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes a single glycoprotein of 520kDa, identified as mucin 2 (MUC2). This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC3. Its epitope has been defined as GTQTP (GlyThrGlnThrPro). Mucins are high molecular weight glycoproteins, which constitute the major component of the mucus layer that protects the gastric epithelium. MUC2 is specifically expressed in goblet cells of the small intestine & colon; in about 65% of colonic carcinomas and about 40% of gastric carcinomas. MUC2 is rarely expressed outside of the GI tract with the exceptions of mucinous carcinoma of breast and clear cell-type carcinomas of the ovary.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
520kDa
OMIM
158370
3D Structure
ModBase 3D Structure for Q02817
Cellular Localization
Cytoplasmic and Cell Surface
Immunogen
A synthetic peptide of 29 amino acids, KYPTTTPISTTTMVTPTPTPTGTQTPTTT from MUC2 protein, coupled to KLH.
Hu-Chromosome Location
11p15.5
Positive Control
LS174T cells or small intestine.
Applications Tested/Suitable for anti-MUC2 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-MUC2 antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-MUC2 antibody

Formalin-fixed, paraffin-embedded human Intestine stained with MUC2 Monoclonal Antibody (CCP58).
Mouse Anti-MUC2 Monoclonal Antibody – Cat# MBS438360

Immunohistochemistry (IHC) of anti-MUC2 antibody

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC2 Monoclonal Antibody (CCP58).
Mouse Anti-MUC2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438360

Product References and Citations for anti-MUC2 antibody

Xing PX, Prenzoska J, Layton GT, Devine PL, McKenzie IF. Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer. J Natl Cancer Inst. 1992; 84(9):699-703

Other Notes

Small volumes of anti-MUC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MUC2. It may not necessarily be applicable to this product.

NCBI GI #
557129045
NCBI GeneID
4583
NCBI Accession #
NP_002448.3
UniProt Primary Accession #
Q02817
UniProt Secondary Accession #
Q14878
UniProt Related Accession #
Q02817
GenBank Nucleotide #
NM_002457.3
NCBI Official Full Name
mucin-2
NCBI Official Synonym Full Names
mucin 2, oligomeric mucus/gel-forming
NCBI Official Symbol
MUC2
NCBI Official Synonym Symbols
MLP; SMUC; MUC-2
UniProt Protein Name
Mucin-2
UniProt Synonym Protein Names
Intestinal mucin-2
Protein Family
Mucin
UniProt Gene Name
MUC2
UniProt Synonym Gene Names
SMUC; MUC-2
UniProt Entry Name
MUC2_HUMAN
NCBI Protein Information
mucin-2

NCBI Summary for MUC2

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
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UniProt Comments for MUC2

MUC2: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi lumen

Molecular Function: protein binding

Biological Process: maintenance of gastrointestinal epithelium; O-glycan processing
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Research Articles on MUC2

1. There was no significant difference in MUC2 expression between chronic rhinosinusitis patients with and without bacterial biofilm formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MUC2 antibody

 Reference Product  PubMed Publications
 MUC1 antibody  >613 publications with MUC2 and MUC1
 MUC4 antibody  >225 publications with MUC2 and MUC4
 MUC7 antibody  >68 publications with MUC2 and MUC7
 MUC16 antibody  >21 publications with MUC2 and MUC16
 MUC17 antibody  >16 publications with MUC2 and MUC17
 MUC3A antibody  >11 publications with MUC2 and MUC3A
 MUC12 antibody  >9 publications with MUC2 and MUC12

Pathways associated with anti-MUC2 antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Defective C1GALT1C1 Causes Tn Polyagglutination Syndrome (TNPS) Pathway antibodies  Defective C1GALT1C1 Causes Tn Polyagglutination Syndrome (TNPS) Pathway Diagram
 Defective GALNT12 Causes Colorectal Cancer 1 (CRCS1) Pathway antibodies  Defective GALNT12 Causes Colorectal Cancer 1 (CRCS1) Pathway Diagram
 Defective GALNT3 Causes Familial Hyperphosphatemic Tumoral Calcinosis (HFTC) Pathway antibodies  Defective GALNT3 Causes Familial Hyperphosphatemic Tumoral Calcinosis (HFTC) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With O-glycosylation Of Proteins Pathway antibodies  Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
 Diseases Of Glycosylation Pathway antibodies  Diseases Of Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram

Diseases associated with anti-MUC2 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >635 publications with MUC2 and Adenocarcinoma
 Intestinal Neoplasms Antibodies  >593 publications with MUC2 and Intestinal Neoplasms
 Pancreatic Neoplasms Antibodies  >180 publications with MUC2 and Pancreatic Neoplasms
 Inflammation Antibodies  >173 publications with MUC2 and Inflammation
 Adenoma Antibodies  >167 publications with MUC2 and Adenoma
 Colitis Antibodies  >127 publications with MUC2 and Colitis
 Neoplasm Metastasis Antibodies  >106 publications with MUC2 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >76 publications with MUC2 and Cell Transformation, Neoplastic
 Precancerous Conditions Antibodies  >73 publications with MUC2 and Precancerous Conditions
 Liver Neoplasms Antibodies  >72 publications with MUC2 and Liver Neoplasms

Organs/Tissues associated with anti-MUC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >631 publications with MUC2 and Intestine
 Stomach Antibodies  >343 publications with MUC2 and Stomach
 Blood Antibodies  >107 publications with MUC2 and Blood
 Muscle Antibodies  >55 publications with MUC2 and Muscle
 Kidney Antibodies  >25 publications with MUC2 and Kidney
 Thyroid Antibodies  >19 publications with MUC2 and Thyroid
 Ascites Antibodies  >12 publications with MUC2 and Ascites
 Brain Antibodies  >9 publications with MUC2 and Brain
 Placenta Antibodies  >3 publications with MUC2 and Placenta
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