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KIF5B Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9467097

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KIF5B, Monoclonal Antibody
Full Product Name
KIF5B Rabbit mAb
Product Gene Name
anti-KIF5B antibody
Product Synonym Names
KNS; KINH; KNS1; UKHC; HEL-S-61
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
S04-6G8
Host
Recombinant Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purity/Purification
Affinity Purified
Concentration
0.3mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
Molecular Weight
109,685 Da
OMIM
602809
3D Structure
ModBase 3D Structure for P33176
Immunogen
A synthetic peptide of human KIF5B
Conjugation
Unconjugated
Modification
Unmodification

Product Categories/Family for anti-KIF5B antibody

Primary Antibody
Applications Tested/Suitable for anti-KIF5B antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-KIF5B antibody
WB: 1/1000-1/5000
IHC: 1/20-1/100
ICC/IF: 1/20-1/100

Western Blot (WB) of anti-KIF5B antibody

Western blot detection of KIF5B in Hela,MCF7,U251MG,K562 cell lysates using KIF5B Rabbit mAb(1:500 diluted).Predicted band size:110kDa.Observed band size:110kDa.
Rabbit Anti-KIF5B Monoclonal Antibody – Cat# MBS9467097

Immunofluorescence (IF) of anti-KIF5B antibody

Immunofluorescence of KIF5B (green) in Hela using KIF5B Rabbit mAb at dilution 1/5, and DAPI(blue)
Rabbit Anti-KIF5B Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS9467097

Immunohistochemistry (IHC) of anti-KIF5B antibody

Immunohistochemistry of KIF5B in paraffin-embedded Human breast cancer tissue using KIF5B Rabbit mAb at dilution 1/50
Rabbit Anti-KIF5B Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9467097

Other Notes

Small volumes of anti-KIF5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIF5B purchase

MBS9467097 is an antibody targeting KIF5B. Also known as KIF5B Rabbit mAb. Reactive in Human, Mouse, Rat. Host: Recombinant Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KIF5B. It may not necessarily be applicable to this product.

NCBI GI #
119606383
NCBI GeneID
3799
NCBI Accession #
EAW85977.1
UniProt Primary Accession #
P33176
UniProt Secondary Accession #
Q5VZ85; A0AVB2
UniProt Related Accession #
P33176
NCBI Official Full Name
kinesin family member 5B, isoform CRA_a
NCBI Official Synonym Full Names
kinesin family member 5B
NCBI Official Symbol
KIF5B
NCBI Official Synonym Symbols
KNS; KINH; KNS1; UKHC; HEL-S-61
UniProt Protein Name
Kinesin-1 heavy chain
UniProt Synonym Protein Names
Conventional kinesin heavy chain; Ubiquitous kinesin heavy chain
Protein Family
Kinesin
UniProt Gene Name
KIF5B
UniProt Synonym Gene Names
KNS; KNS1; UKHC
UniProt Entry Name
KINH_HUMAN
NCBI Protein Information
kinesin-1 heavy chain; kinesin heavy chain; kinesin 1 (110-120kD); ubiquitous kinesin heavy chain; conventional kinesin heavy chain; epididymis secretory protein Li 61

UniProt Comments for KIF5B

KIF5B: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Belongs to the kinesin-like protein family. Kinesin subfamily.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 10p11.22

Cellular Component: ciliary rootlet; microtubule; kinesin complex; neuron projection; membrane; endocytic vesicle; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; vesicle

Molecular Function: protein binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: axon guidance; regulation of membrane potential; cellular protein metabolic process; positive regulation of potassium ion transport; vesicle transport along microtubule; positive regulation of synaptic transmission, GABAergic; cytoplasm organization and biogenesis; cytoskeleton-dependent intracellular transport; microtubule-based movement
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Research Articles on KIF5B

1. Anti-oncogenic miR-203 had a pivotal role in melanoma through reducing melanosome transport and promoting melanogenesis by targeting kif5b and through negative regulation of the CREB1/MITF/Rab27a pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KIF5B antibody

 Reference Product  PubMed Publications
 KLC1 antibody  >12 publications with KIF5B and KLC1
 KLC2 antibody  >5 publications with KIF5B and KLC2
 RANBP2 antibody  >4 publications with KIF5B and RANBP2
 VAMP2 antibody  >2 publications with KIF5B and VAMP2
 INS antibody  >1 publications with KIF5B and INS
 MYO5A antibody  >1 publications with KIF5B and MYO5A
 KLC3 antibody  >1 publications with KIF5B and KLC3

Pathways associated with anti-KIF5B antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
 Kinesins Pathway antibodies  Kinesins Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram

Diseases associated with anti-KIF5B antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >40 publications with KIF5B and Neoplasms
 Adenocarcinoma Antibodies  >29 publications with KIF5B and Adenocarcinoma
 Carcinoma, Non-Small-Cell Lung Antibodies  >21 publications with KIF5B and Carcinoma, Non-Small-Cell Lung
 Nervous System Diseases Antibodies  >10 publications with KIF5B and Nervous System Diseases
 Congenital Abnormalities Antibodies  >3 publications with KIF5B and Congenital Abnormalities
 Inflammation Antibodies  >2 publications with KIF5B and Inflammation
 Hypertrophy Antibodies  >2 publications with KIF5B and Hypertrophy
 Pain Antibodies  >1 publications with KIF5B and Pain
 Cognition Disorders Antibodies  >1 publications with KIF5B and Cognition Disorders
 Nerve Degeneration Antibodies  >1 publications with KIF5B and Nerve Degeneration

Organs/Tissues associated with anti-KIF5B antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >43 publications with KIF5B and Lung
 Brain Antibodies  >30 publications with KIF5B and Brain
 Nerve Antibodies  >17 publications with KIF5B and Nerve
 Muscle Antibodies  >13 publications with KIF5B and Muscle
 Heart Antibodies  >9 publications with KIF5B and Heart
 Blood Antibodies  >7 publications with KIF5B and Blood
 Eye Antibodies  >5 publications with KIF5B and Eye
 Lymph Node Antibodies  >4 publications with KIF5B and Lymph Node
 Embryonic Tissue Antibodies  >4 publications with KIF5B and Embryonic Tissue
 Lymph Antibodies  >4 publications with KIF5B and Lymph
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