SNX16 Antibody – Goat Polyclonal

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein has not been determined. This gene results in three transcript variants encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

SNX16: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: lysosome; late endosome membrane; early endosome membrane; early endosome; late endosome

Molecular Function: identical protein binding; phosphoinositide binding

Biological Process: protein targeting to lysosome; early endosome to late endosome transport; endosome to lysosome transport