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ELAC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246741

MBS246741 is an antibody targeting ELAC2. Also known as Rabbit Polyclonal (IgG) to Human ELAC2 / HPC2. Reactive in Human. Host: Rabbit. Mutations in this gene segregate with prostate cancer. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ELAC2 / HPC2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human ELAC2 / HPC2
Product Gene Name
Product Synonym Gene Name
HPC2
Product Synonym Names
Anti-ELAC2 / HPC2 Antibody (aa161-210) IHC-plus; ELAC2; ElaC (E Coli) homolog 2; ElaC homolog 2 (E Coli); ELC2; ElaC homolog protein 2; HPC2; RNase Z 2; Ribonuclease Z 2; TRNA 3 endonuclease 2; TRNase Z (long form); TRNase Z 2; Human ELAC2; HPC2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
ELAC2 Antibody detects endogenous levels of total ELAC2 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
87,564 Da
OMIM
phenotype 615440
3D Structure
ModBase 3D Structure for Q9BQ52
Target Species
Human
Immunogen Description
Synthetic peptide from human ELAC2 (aa161-210).
Immunogen
ELAC2 / HPC2 antibody was raised against synthetic peptide from human ELAC2 (aa161-210).
Antigen Modification
aa161-210
Applications Tested/Suitable for anti-ELAC2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-ELAC2 antibody
ELISA (1:10000), IHC-P (10 ug/ml)

Immunohistochemistry (IHC) of anti-ELAC2 antibody

Anti-ELAC2 antibody IHC of human breast, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ELAC2 Polyclonal Antibody – Cat# MBS246741

Immunohistochemistry (IHC) of anti-ELAC2 antibody

Anti-ELAC2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ELAC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246741

Other Notes

Small volumes of anti-ELAC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ELAC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
zinc phosphodiesterase ELAC protein 2 isoform 1
NCBI Official Synonym Full Names
elaC ribonuclease Z 2
NCBI Official Symbol
ELAC2
NCBI Official Synonym Symbols
ELC2; HPC2; COXPD17
UniProt Protein Name
Zinc phosphodiesterase ELAC protein 2
UniProt Synonym Protein Names
ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2
UniProt Gene Name
ELAC2
UniProt Synonym Gene Names
HPC2; RNase Z 2
UniProt Entry Name
RNZ2_HUMAN
NCBI Protein Information
zinc phosphodiesterase ELAC protein 2; RNase Z 2; tRNase Z 2; elaC homolog 2; ribonuclease Z 2; tRNase Z (long form); tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2

NCBI Summary for ELAC2

The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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UniProt Comments for ELAC2

ELAC2: a zinc phosphodiesterase. Putative prostate cancer susceptibility protein.

Protein type: Phosphodiesterase; EC 3.1.26.11; Oncoprotein; Ribonuclease; RNA processing

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: endonuclease activity; metal ion binding

Disease: Prostate Cancer, Hereditary, 2; Combined Oxidative Phosphorylation Deficiency 17
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ELAC2 antibody

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