ESRRB Antibody – Rabbit Polyclonal

ERR2: Nuclear receptor, may regulate ESR1 transcriptional activity. Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35). DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; transcription factor binding; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; embryonic placenta development; intracellular receptor-mediated signaling pathway; trophectodermal cell proliferation; regulation of transcription, DNA-dependent; stem cell maintenance; trophectodermal cellular morphogenesis; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression

Disease: Deafness, Autosomal Recessive 35