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MRGPRX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246850

MRGX2 is highly similar to other MRG receptors. Recently it has been shown that MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
MRGPRX2 / MRGX2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MRGPRX2 / MRGX2
Product Gene Name
anti-MRGPRX2 antibody
Product Synonym Gene Name
MRGX2
Product Synonym Names
Anti-MRGPRX2 / MRGX2 Antibody (C-Terminus) IHC-plus; MRGPRX2; MRGX2; MAS-related GPR; member X2; Human MRGPRX2; MRGX2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Chimpanzee, Human, Orangutan
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human MRGPRX2 / MRGX2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
37,099 Da
OMIM
607228
3D Structure
ModBase 3D Structure for Q96LB1
Target Species
Human
Immunogen Description
Synthetic 14 amino acid peptide from C-terminus of human MRGPRX2 / MRGX2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon (100%); Gorilla, Monkey (93%).
Immunogen Type
Synthetic peptide
Immunogen
MRGPRX2 / MRGX2 antibody was raised against synthetic 14 amino acid peptide from C-terminus of human MRGPRX2 / MRGX2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon (100%); Gorilla, Monkey (93%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-MRGPRX2 antibody

Family: GPCR; Subfamily: Proadrenomedullin N-terminal peptide
Applications Tested/Suitable for anti-MRGPRX2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-MRGPRX2 antibody
IHC-P (7 - 18 ug/ml)

Immunohistochemistry (IHC) of anti-MRGPRX2 antibody

Anti-MRGPRX2 / MRGX2 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGPRX2 Polyclonal Antibody – Cat# MBS246850

Immunohistochemistry (IHC) of anti-MRGPRX2 antibody

Anti-MRGPRX2 / MRGX2 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGPRX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246850

Immunohistochemistry (IHC) of anti-MRGPRX2 antibody

Anti-MRGPRX2 / MRGX2 antibody IHC of human spinal cord, dorsal root ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGPRX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246850

Other Notes

Small volumes of anti-MRGPRX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRGPRX2 purchase

MBS246850 is an antibody targeting MRGPRX2. Also known as Rabbit Polyclonal to Human MRGPRX2 / MRGX2. Reactive in Gibbon, Chimpanzee, Human, Orangutan
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MRGPRX2. It may not necessarily be applicable to this product.

NCBI GI #
16876451
NCBI GeneID
117194
NCBI Accession #
NP_473371.1
UniProt Primary Accession #
Q96LB1
UniProt Secondary Accession #
Q4QXW4; Q4QXW7; Q4QXX0; Q4QXX2; Q4QXX3; Q4QXX4; Q4QXX6; Q4QXX7; B5B0C7
UniProt Related Accession #
Q96LB1
GenBank Nucleotide #
NM_054030.2
NCBI Official Full Name
mas-related G-protein coupled receptor member X2
NCBI Official Synonym Full Names
MAS-related GPR, member X2
NCBI Official Symbol
MRGPRX2
NCBI Official Synonym Symbols
MGRG3; MRGX2
UniProt Protein Name
Mas-related G-protein coupled receptor member X2
Protein Family
Mas-related G-protein coupled receptor
UniProt Gene Name
MRGPRX2
UniProt Synonym Gene Names
MRGX2
UniProt Entry Name
MRGX2_HUMAN
NCBI Protein Information
mas-related G-protein coupled receptor member X2; G protein-coupled receptor MRGX2; Mas-related G protein-coupled receptor G3

UniProt Comments for MRGPRX2

MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; sleep; sensory perception of pain
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Research Articles on MRGPRX2

1. Ectopic expression of MrgX2 in rat basophilic leukemia RBL-2H3 cells and murine bone marrow mast cells renders these cells responsive to human beta-defensin for degranulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-MRGPRX2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with MRGPRX2 and Inflammation
 Nervous System Diseases Antibodies  >2 publications with MRGPRX2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >1 publications with MRGPRX2 and Adenocarcinoma
 Brain Diseases Antibodies  >1 publications with MRGPRX2 and Brain Diseases
 Neurologic Manifestations Antibodies  >1 publications with MRGPRX2 and Neurologic Manifestations
 Lung Diseases Antibodies  >1 publications with MRGPRX2 and Lung Diseases

Organs/Tissues associated with anti-MRGPRX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with MRGPRX2 and Brain
 Testis Antibodies  >2 publications with MRGPRX2 and Testis
 Bone Marrow Antibodies  >1 publications with MRGPRX2 and Bone Marrow
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