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ANXA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246858

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which… More details

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Product Overview

Product Name
ANXA2 / Annexin A2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ANXA2 / Annexin A2
Product Gene Name
anti-ANXA2 antibody
Product Synonym Names
Anti-ANXA2 / Annexin A2 Antibody (N-Terminus) IHC-plus; ANXA2; Annexin A2; Annexin-2; ANX2; Calpactin I heavy chain; Chromobindin-8; CAL1H; Calpactin I heavy polypeptide; Chromobindin 8; LPC2; LIP2; Lipocortin II; p36; LPC2D; PAP-IV; Protein I; Annexin II; ANX2L4; Calpactin-1 heavy chain; Human ANXA2; Annexin A2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Ammonium sulfate precipitation
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
Molecular Weight
40,411 Da
OMIM
151740
3D Structure
ModBase 3D Structure for P07355
Target Species
Human
Immunogen Description
KLH conjugated synthetic peptide selected from the N-terminal region of human ANXA2.
Immunogen Type
Synthetic peptide
Immunogen
ANXA2 / Annexin A2 antibody was raised against kLH conjugated synthetic peptide selected from the N-terminal region of human ANXA2.
Antigen Modification
N-Terminus

Product Categories/Family for anti-ANXA2 antibody

Family: Annexin
Applications Tested/Suitable for anti-ANXA2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ANXA2 antibody
IHC-P (10 ug/ml), WB (1:1000)
Usage: Please note that cross-reactivity of this antibody with mouse has been confirmed in WB only. The antibody has not been evaluated for use with mouse in alternate assays, including IHC, at this time. It the absence of testing data we unfortunately ca...

Immunohistochemistry (IHC) of anti-ANXA2 antibody

Anti-Annexin A2 antibody IHC of human placental vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ANXA2 Polyclonal Antibody – Cat# MBS246858

Immunohistochemistry (IHC) of anti-ANXA2 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ANXA2 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-ANXA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246858

Western Blot (WB) of anti-ANXA2 antibody

ANXA2 Antibody (N-term) western blot analysis in 293,MDA-MB231 cell line lysates (35 ug/lane).This demonstrates the ANXA2 antibody detected the ANXA2 protein (arrow).
Rabbit Anti-ANXA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS246858

Western Blot (WB) of anti-ANXA2 antibody

Western blot analysis of anti-ANXA2 Antibody (N-term) in mouse lung tissue lysates (35 ug/lane). ANXA2(arrow) was detected using the purified Pab.
Rabbit Anti-ANXA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS246858

Western Blot (WB) of anti-ANXA2 antibody

Western blot analysis of ANXA2 (arrow) using rabbit polyclonal ANXA2 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ANXA2 gene.
Rabbit Anti-ANXA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS246858

Western Blot (WB) of anti-ANXA2 antibody

Western blot of ANXA2 antibody on 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with ANXA2.
Rabbit Anti-ANXA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS246858

Other Notes

Small volumes of anti-ANXA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA2 purchase

MBS246858 is an antibody targeting ANXA2. Also known as Rabbit Polyclonal to Human ANXA2 / Annexin A2. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA2. It may not necessarily be applicable to this product.

NCBI GI #
50845388
NCBI GeneID
302
NCBI Accession #
NP_001002858.1
UniProt Primary Accession #
P07355
UniProt Secondary Accession #
Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8
UniProt Related Accession #
P07355
GenBank Nucleotide #
NM_001002858.2
NCBI Official Full Name
annexin A2 isoform 1
NCBI Official Synonym Full Names
annexin A2
NCBI Official Symbol
ANXA2
NCBI Official Synonym Symbols
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
UniProt Protein Name
Annexin A2
UniProt Synonym Protein Names
Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
Protein Family
Annexin
UniProt Gene Name
ANXA2
UniProt Synonym Gene Names
ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV
UniProt Entry Name
ANXA2_HUMAN
NCBI Protein Information
annexin A2; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; calpactin I heavy polypeptide; placental anticoagulant protein IV; epididymis secretory protein Li 270

NCBI Summary for ANXA2

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ANXA2

ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: extrinsic to plasma membrane; extracellular space; protein complex; cell surface; lysosomal membrane; late endosome membrane; early endosome; lipid particle; cell cortex; lipid raft; ruffle; extracellular matrix; membrane; perinuclear region of cytoplasm; plasma membrane; melanosome; basement membrane; midbody; nucleus; endosome; vesicle; sarcolemma

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; calcium-dependent protein binding; Rab GTPase binding

Biological Process: positive regulation of fibroblast proliferation; fibrinolysis; collagen fibril organization; negative regulation of catalytic activity; positive regulation of vesicle fusion; protein heterotetramerization; angiogenesis; positive regulation of binding; positive regulation of protein amino acid phosphorylation; body fluid secretion; lipid raft formation; membrane budding
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Research Articles on ANXA2

1. Annexin A2 is a key molecule in the DDR-2/annexin A2/MMP-13 loop, the activation of which contributes to joint destruction in rheumatoid arthritis, mainly through promoting invasion of fibroblast-like synoviocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANXA2 antibody

 Reference Product  PubMed Publications
 S100A10 antibody  >125 publications with ANXA2 and S100A10
 SRC antibody  >35 publications with ANXA2 and SRC
 S100A6 antibody  >18 publications with ANXA2 and S100A6
 S100A4 antibody  >16 publications with ANXA2 and S100A4
 PLG antibody  >11 publications with ANXA2 and PLG
 PLAT antibody  >8 publications with ANXA2 and PLAT
 TRPV5 antibody  >7 publications with ANXA2 and TRPV5
 DYSF antibody  >3 publications with ANXA2 and DYSF
 CEACAM1 antibody  >1 publications with ANXA2 and CEACAM1

Pathways associated with anti-ANXA2 antibody

 Products by Pathway  Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ANXA2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >98 publications with ANXA2 and Inflammation
 Adenocarcinoma Antibodies  >83 publications with ANXA2 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >69 publications with ANXA2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >62 publications with ANXA2 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >62 publications with ANXA2 and Neoplasm Metastasis
 Necrosis Antibodies  >48 publications with ANXA2 and Necrosis
 Neoplasm Invasiveness Antibodies  >44 publications with ANXA2 and Neoplasm Invasiveness
 Liver Diseases Antibodies  >44 publications with ANXA2 and Liver Diseases
 Brain Diseases Antibodies  >39 publications with ANXA2 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >38 publications with ANXA2 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-ANXA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >232 publications with ANXA2 and Blood
 Vascular Antibodies  >162 publications with ANXA2 and Vascular
 Lung Antibodies  >107 publications with ANXA2 and Lung
 Brain Antibodies  >100 publications with ANXA2 and Brain
 Liver Antibodies  >84 publications with ANXA2 and Liver
 Muscle Antibodies  >81 publications with ANXA2 and Muscle
 Kidney Antibodies  >67 publications with ANXA2 and Kidney
 Bone Antibodies  >63 publications with ANXA2 and Bone
 Embryonic Tissue Antibodies  >51 publications with ANXA2 and Embryonic Tissue
 Intestine Antibodies  >38 publications with ANXA2 and Intestine
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