PARD3 Antibody – Rabbit Polyclonal

This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

PAR3-alpha: an adapter protein involved in asymmetrical cell division, and cell polarization processes. Polarity complex proteins, including PARD3, are essential for PIP3-induced receptor tyrosine kinase recycling. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. PDZ 1 domain modulates interactions with JAM1, PARD6A and PARD6B; PDZ 2 domain mediates interaction with membranes containing phosphoinositol lipids; PDZ 3 domain regulates interactions with PTEN (via C-terminus). Belongs to the PAR3 family. 10 isoforms of the human protein are produced by alternative splicing. Isoform 2, but not at least isoform 3 interacts with PRKCZ.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p11.21

Cellular Component: tight junction; protein complex; endomembrane system; intercellular junction; cell cortex; cytosol; internode region of axon; cell-cell adherens junction; cell soma; apical part of cell; plasma membrane; spindle; cell junction

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; protein kinase C binding; protein phosphatase binding; phosphatidylinositol 3-phosphate binding

Biological Process: positive regulation of myelination; regulation of actin filament-based process; intercellular junction assembly and maintenance; establishment and/or maintenance of cell polarity; microtubule cytoskeleton organization and biogenesis; cell cycle; myelination in the peripheral nervous system; axonogenesis; centrosome localization; asymmetric cell division; transforming growth factor beta receptor signaling pathway; protein kinase C activation; protein complex assembly; protein targeting to membrane