Rabbit Anti-DPEP1 Polyclonal Antibody – Cat# MBS247226

Anti-DPEP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Renal Dipeptidase / DPEP1 (DPEP1) Antibody – Rabbit Polyclonal

Name: DPEP1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS247226
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247226

MBS247226 is an antibody targeting DPEP1. Also known as Rabbit Polyclonal to Human Renal Dipeptidase / DPEP1. Reactive in HumanPredicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity). Host: Rabbit. More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Renal Dipeptidase / DPEP1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human Renal Dipeptidase / DPEP1

Product Gene Name

anti-DPEP1 antibody

Product Synonym Names

Anti-Renal Dipeptidase / DPEP1 Antibody (N-Terminus) IHC-plus; DPEP1; Dipeptidase 1 (renal); Dehydropeptidase-I; Dipeptidase 1; HRDP; Microsomal dipeptidase; Renal dipeptidase; RDP; Human Renal Dipeptidase; DPEP1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human
Predicted Reactivity: Gorilla, Monkey (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human DPEP1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

45,674 Da

OMIM

179780

3D Structure

ModBase 3D Structure for P16444

Target Species

Human

Immunogen Description

Synthetic 18 amino acid peptide from N-Terminus of human DPEP1. Percent identity with other species by BLAST analysis: Human, Monkey (100%); Gorilla, Marmoset (94%).

Immunogen Type

Synthetic peptide

Immunogen

Renal Dipeptidase / DPEP1 antibody was raised against synthetic 18 amino acid peptide from N-Terminus of human DPEP1. Percent identity with other species by BLAST analysis: Human, Monkey (100%); Gorilla, Marmoset (94%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-DPEP1 antibody

Family: Exopeptidase; Subfamily: Metallopeptidase M19

Applications Tested/Suitable for anti-DPEP1 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-DPEP1 antibody

IHC-P (2.5 ug/ml)

Other Notes

Small volumes of anti-DPEP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DPEP1. It may not necessarily be applicable to this product.

NCBI GI #

4758190

NCBI GeneID

1800

NCBI Accession #

NP_004404.1

UniProt Primary Accession #

P16444

UniProt Secondary Accession #

Q96AK2; D3DX80

UniProt Related Accession #

P16444

GenBank Nucleotide #

NM_004413.3

NCBI Official Full Name

dipeptidase 1

NCBI Official Synonym Full Names

dipeptidase 1 (renal)

NCBI Official Symbol

DPEP1

NCBI Official Synonym Symbols

MDP; RDP; MBD1

UniProt Protein Name

Dipeptidase 1

UniProt Synonym Protein Names

Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP

Protein Family

Dipeptidase

UniProt Gene Name

DPEP1

UniProt Synonym Gene Names

MDP; RDP; hRDP

UniProt Entry Name

DPEP1_HUMAN

NCBI Protein Information

dipeptidase 1; hRDP; renal dipeptidase; dehydropeptidase-I; microsomal dipeptidase

NCBI Summary for DPEP1

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

UniProt Comments for DPEP1

DPEP1: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family.

Protein type: Membrane protein, GPI anchor; EC 3.4.13.19; Protease

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: extracellular space; microvillus membrane; apical part of cell; apical plasma membrane; plasma membrane; cell junction; nucleus

Molecular Function: protein binding; metalloexopeptidase activity; zinc ion binding; dipeptidyl-peptidase activity; caspase inhibitor activity

Biological Process: glutathione metabolic process; xenobiotic metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; negative regulation of caspase activity; homocysteine metabolic process; proteolysis; negative regulation of cell migration; antibiotic metabolic process; negative regulation of apoptosis

Research Articles on DPEP1

1. Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DPEP1 antibody

Products by Pathway	Pathway Diagram
Aflatoxin Activation And Detoxification Pathway antibodies	Aflatoxin Activation And Detoxification Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Defective ACY1 Causes Encephalopathy Pathway antibodies	Defective ACY1 Causes Encephalopathy Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Eicosanoid Synthesis Pathway antibodies	Eicosanoid Synthesis Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway antibodies	Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway Diagram

Diseases associated with anti-DPEP1 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>2 publications with DPEP1 and Heart Diseases
Cell Transformation, Neoplastic Antibodies	>2 publications with DPEP1 and Cell Transformation, Neoplastic
Ovarian Diseases Antibodies	>1 publications with DPEP1 and Ovarian Diseases
Breast Neoplasms Antibodies	>1 publications with DPEP1 and Breast Neoplasms
Kidney Diseases Antibodies	>1 publications with DPEP1 and Kidney Diseases

Organs/Tissues associated with anti-DPEP1 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>4 publications with DPEP1 and Kidney
Intestine Antibodies	>3 publications with DPEP1 and Intestine
Lymph Node Antibodies	>2 publications with DPEP1 and Lymph Node
Pancreas Antibodies	>1 publications with DPEP1 and Pancreas