Rabbit Anti-HRH2 Polyclonal Antibody – Cat# MBS247238

Anti-HRH2 / Histamine H2 Receptor antibody IHC of human stomach, parietal cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HRH2 Antibody – Rabbit Polyclonal

Name: HRH2 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS247238
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247238

H2 Histamine Receptor stimulates adenylate cyclase activity and leads to the release of acids in the stomach. It is also involved in GI motility and intestinal secretion. Treatments for acid-peptic disorders are based on the inhibition of histamine H2… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HRH2 / Histamine H2 Receptor, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human HRH2 / Histamine H2 Receptor

Product Gene Name

anti-HRH2 antibody

Product Synonym Names

Anti-HRH2 / Histamine H2 Receptor Antibody (Cytoplasmic Domain) IHC-plus; HRH2; Gastric receptor I; H2R; Histamine 2 receptor; Gastric receptor 1; H2 histamine receptor; HH2R; Histamine type 2 receptor; Histamine H2 receptor; Histamine receptor H2; Human HRH2; Histamine H2 Receptor

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human HRH2 / Histamine H2 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

44,541 Da

OMIM

142703

3D Structure

ModBase 3D Structure for P25021

Target Species

Human

Immunogen Description

Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human HRH2 / Histamine H2 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey (100%); Mouse, Rat, Hamster (94%).

Immunogen Type

Synthetic peptide

Immunogen

HRH2 / Histamine H2 Receptor antibody was raised against synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human HRH2 / Histamine H2 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey (100%); Mouse, Rat, Hamster (94%); Elephant (88%); Dog, Bat, Rabbit, Guinea pig (81%).

Antigen Modification

Cytoplasmic Domain

Product Categories/Family for anti-HRH2 antibody

Family: GPCR; Subfamily: Histamine

Applications Tested/Suitable for anti-HRH2 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-HRH2 antibody

IHC-P (38 ug/ml)

Other Notes

Small volumes of anti-HRH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HRH2 purchase

MBS247238 is an antibody targeting HRH2. Also known as Rabbit Polyclonal to Human HRH2 / Histamine H2 Receptor. Reactive in Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HRH2. It may not necessarily be applicable to this product.

NCBI GI #

13435405

NCBI GeneID

3274

NCBI Accession #

NP_071640.1

UniProt Primary Accession #

P25021

UniProt Secondary Accession #

Q14464; Q7Z5R9; B5BUP7

UniProt Related Accession #

P25021

GenBank Nucleotide #

NM_022304.2

NCBI Official Full Name

histamine H2 receptor isoform 2

NCBI Official Synonym Full Names

histamine receptor H2

NCBI Official Symbol

HRH2

NCBI Official Synonym Symbols

H2R

UniProt Protein Name

Histamine H2 receptor

UniProt Synonym Protein Names

Gastric receptor I

Protein Family

Histamine H2 receptor

UniProt Gene Name

HRH2

UniProt Synonym Gene Names

H2R; HH2R

UniProt Entry Name

HRH2_HUMAN

NCBI Protein Information

histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I

NCBI Summary for HRH2

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

UniProt Comments for HRH2

H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: histamine receptor activity

Biological Process: gland development; G-protein signaling, coupled to cyclic nucleotide second messenger; gastrin-induced gastric acid secretion; gut development; histamine-induced gastric acid secretion; positive regulation of vasoconstriction; regulation of synaptic plasticity; visual learning; immune response; memory

Research Articles on HRH2

1. But carriers of one or three copies of HRH1 (5% of individuals), HRH2 (1.1%) and HRH4 genes (0.9%) were also identified.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HRH2 antibody

Reference Product	PubMed Publications
JUN antibody	>4 publications with HRH2 and JUN
HDC antibody	>2 publications with HRH2 and HDC
ATP4A antibody	>2 publications with HRH2 and ATP4A

Pathways associated with anti-HRH2 antibody

Products by Pathway	Pathway Diagram
Amine Ligand-binding Receptors Pathway antibodies	Amine Ligand-binding Receptors Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-HRH2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>3 publications with HRH2 and Carcinoma
Inflammation Antibodies	>2 publications with HRH2 and Inflammation
Pain Antibodies	>2 publications with HRH2 and Pain
Seizures Antibodies	>2 publications with HRH2 and Seizures
Neoplasms, Experimental Antibodies	>2 publications with HRH2 and Neoplasms, Experimental
Ulcer Antibodies	>1 publications with HRH2 and Ulcer
Peptic Ulcer Antibodies	>1 publications with HRH2 and Peptic Ulcer

Organs/Tissues associated with anti-HRH2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with HRH2 and Brain
Skin Antibodies	>2 publications with HRH2 and Skin