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AFAP1L2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247299

MBS247299 is an antibody targeting AFAP1L2. Also known as Rabbit Polyclonal to Human AFAP1L2 / XB130. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
AFAP1L2 / XB130, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human AFAP1L2 / XB130
Product Gene Name
Product Synonym Gene Name
XB130
Product Synonym Names
Anti-AFAP1L2 / XB130 Antibody (C-Terminus) IHC-plus; AFAP1-like protein 2; CTB-1144G6.4; KIAA1914; Human AFAP1L2; XB130
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human KIAA1914
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
93,894 Da
OMIM
612420
3D Structure
ModBase 3D Structure for Q8N4X5
Target Species
Human
Immunogen Description
A 15 amino acid peptide near the carboxy terminus of human AFAP1L2.
Immunogen Type
Synthetic peptide
Immunogen
AFAP1L2 / XB130 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human AFAP1L2.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-AFAP1L2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-AFAP1L2 antibody
ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: AFAP1L2 antibody can be used for detection of AFAP1L2 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-AFAP1L2 antibody

Anti-AFAP1L2 / KIAA1914 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-AFAP1L2 Polyclonal Antibody – Cat# MBS247299

Immunohistochemistry (IHC) of anti-AFAP1L2 antibody

Anti-AFAP1L2 / KIAA1914 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-AFAP1L2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247299

Immunofluorescence (IF) of anti-AFAP1L2 antibody

Immunofluorescence of AFAP1L2 in human liver tissue with AFAP1L antibody at 20 ug/ml.
Rabbit Anti-AFAP1L2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247299

Western Blot (WB) of anti-AFAP1L2 antibody

Western blot of AFAP1L2 in mouse liver tissue lysate with AFAP1L2 antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-AFAP1L2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247299

Other Notes

Small volumes of anti-AFAP1L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AFAP1L2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
actin filament-associated protein 1-like 2 isoform 1
NCBI Official Synonym Full Names
actin filament associated protein 1-like 2
NCBI Official Symbol
AFAP1L2
NCBI Official Synonym Symbols
XB130; KIAA1914; CTB-1144G6.4
UniProt Protein Name
Actin filament-associated protein 1-like 2
UniProt Gene Name
AFAP1L2
UniProt Synonym Gene Names
KIAA1914; XB130; AFAP1-like protein 2
UniProt Entry Name
AF1L2_HUMAN
NCBI Protein Information
actin filament-associated protein 1-like 2; AFAP1-like protein 2

UniProt Comments for AFAP1L2

AFAP1L2: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Activator

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding

Biological Process: positive regulation of interleukin-8 production; positive regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of mitotic cell cycle; regulation of interleukin-6 production; inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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