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EIF4A2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247635

MBS247635 is an antibody targeting EIF4A2. Also known as Rabbit Polyclonal (IgG) to Human EIF4A2. Reactive in Chimpanzee, Chicken, Dog, Human, Macaque, Monkey, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
EIF4A2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human EIF4A2
Product Gene Name
anti-EIF4A2 antibody
Product Synonym Names
Anti-EIF4A2 Antibody (aa50-100) IHC-plus; EIF4A2; BM-010; EIF-4A-II; EIF4A; EIF4A-II; EIF4F; DDX2B; Human EIF4A2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Chimpanzee, Chicken, Dog, Human, Macaque, Monkey, Mouse
Form/Format
PBS, 0.05% BSA, 0.05% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human EIF4A2
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
46,489 Da
OMIM
601102
3D Structure
ModBase 3D Structure for Q14240
Target Species
Human
Immunogen Description
A portion of amino acids 50-100 of human eIF4A2 was used as the immunogen.
Immunogen Type
Synthetic peptide
Immunogen
EIF4A2 antibody was raised against a portion of amino acids 50-100 of human eIF4A2 was used as the immunogen.
Antigen Modification
aa50-100
Applications Tested/Suitable for anti-EIF4A2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-EIF4A2 antibody
IHC-P, WB (0.02 - 0.05 ug/ml)

Immunohistochemistry (IHC) of anti-EIF4A2 antibody

Anti-EIF4A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Rabbit Anti-EIF4A2 Polyclonal Antibody – Cat# MBS247635

Western Blot (WB) of anti-EIF4A2 antibody

Western blot of eIF4A2 in Jurkat cell lysate in the 1) absence, 2) presence of immunizing peptide and 3) 3T3 cell lysate using at 0.05 ug/ml, 0.05 ug/ml and 0.025 ug/ml, respectively.
Rabbit Anti-EIF4A2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247635

Other Notes

Small volumes of anti-EIF4A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF4A2. It may not necessarily be applicable to this product.

NCBI GI #
83700235
NCBI GeneID
1974
NCBI Accession #
NP_001958.2
UniProt Primary Accession #
Q14240
UniProt Secondary Accession #
Q53XJ6; Q96B90; Q96EA8; D3DNU9
UniProt Related Accession #
Q14240
GenBank Nucleotide #
NM_001967.3
NCBI Official Full Name
eukaryotic initiation factor 4A-II
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4A2
NCBI Official Symbol
EIF4A2
NCBI Official Synonym Symbols
DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II
UniProt Protein Name
Eukaryotic initiation factor 4A-II
UniProt Synonym Protein Names
ATP-dependent RNA helicase eIF4A-2
Protein Family
Eukaryotic initiation factor
UniProt Gene Name
EIF4A2
UniProt Synonym Gene Names
DDX2B; EIF4F; eIF-4A-II; eIF4A-II
UniProt Entry Name
IF4A2_HUMAN
NCBI Protein Information
eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase eIF4A-2

UniProt Comments for EIF4A2

EIF4A2: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Belongs to the DEAD box helicase family. eIF4A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Translation; RNA-binding; Translation initiation; Helicase

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: perinuclear region of cytoplasm; eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; translation initiation factor activity; ATPase activity; helicase activity; ATP binding

Biological Process: poly(A) tail shortening; cellular protein metabolic process; translation; viral reproduction; cytokine and chemokine mediated signaling pathway; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay; regulation of translational initiation
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Research Articles on EIF4A2

1. expression is an independent prognostic factor for patients with non-small-cell lung cancer for both overall survival and disease-free survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EIF4A2 antibody

 Reference Product  PubMed Publications
 EIF4G1 antibody  >1 publications with EIF4A2 and EIF4G1

Pathways associated with anti-EIF4A2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram

Diseases associated with anti-EIF4A2 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >1 publications with EIF4A2 and Lung Diseases
 Lymphoma Antibodies  >1 publications with EIF4A2 and Lymphoma
 Fibrosis Antibodies  >1 publications with EIF4A2 and Fibrosis
 Fatty Liver Antibodies  >1 publications with EIF4A2 and Fatty Liver
 Lung Neoplasms Antibodies  >1 publications with EIF4A2 and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with EIF4A2 and Liver Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with EIF4A2 and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-EIF4A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with EIF4A2 and Liver
 Muscle Antibodies  >3 publications with EIF4A2 and Muscle
 Brain Antibodies  >3 publications with EIF4A2 and Brain
 Blood Antibodies  >2 publications with EIF4A2 and Blood
 Ovary Antibodies  >1 publications with EIF4A2 and Ovary
 Pancreas Antibodies  >1 publications with EIF4A2 and Pancreas
 Lung Antibodies  >1 publications with EIF4A2 and Lung
 Embryonic Tissue Antibodies  >1 publications with EIF4A2 and Embryonic Tissue
 Kidney Antibodies  >1 publications with EIF4A2 and Kidney
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