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HRS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247661

MBS247661 is an antibody targeting HRS. Also known as Rabbit Polyclonal (IgG) to Human HRS / HGS. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Overview

Product Name
HRS / HGS, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human HRS / HGS
Product Gene Name
anti-HRS antibody
Product Synonym Gene Name
HGS
Product Synonym Names
Anti-HRS / HGS Antibody (aa451-500) IHC-plus; HGS; HRS; Vps27; Protein pp110; ZFYVE8; Human HRS; HGS
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
HGS Antibody detects endogenous levels of total HGS protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
76,376 Da
OMIM
604375
3D Structure
ModBase 3D Structure for O14964
Target Species
Human
Immunogen Description
Synthetic peptide from human HGS (aa451-500).
Immunogen
HRS / HGS antibody was raised against synthetic peptide from human HGS (aa451-500).
Antigen Modification
aa451-500
Applications Tested/Suitable for anti-HRS antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-HRS antibody
ELISA (1:40000), IF (1:100 - 1:500), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-HRS antibody

Anti-HGS antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HRS Polyclonal Antibody – Cat# MBS247661

Immunohistochemistry (IHC) of anti-HRS antibody

Anti-HGS antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HRS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247661

Immunohistochemistry (IHC) of anti-HRS antibody

Anti-HGS antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HRS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247661

Immunofluorescence (IF) of anti-HRS antibody

Immunofluorescence of HUVEC cells, using HGS Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-HRS Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247661

Western Blot (WB) of anti-HRS antibody

Western blot of extracts from 293/HUVEC cells, using HGS Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-HRS Polyclonal Antibody, Western Blot (WB) – Cat# MBS247661

Other Notes

Small volumes of anti-HRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HRS. It may not necessarily be applicable to this product.

NCBI GI #
4758528
NCBI GeneID
9146
NCBI Accession #
NP_004703.1
UniProt Primary Accession #
O14964
UniProt Secondary Accession #
Q9NR36
UniProt Related Accession #
O14964
GenBank Nucleotide #
NM_004712.4
NCBI Official Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate
NCBI Official Synonym Full Names
hepatocyte growth factor-regulated tyrosine kinase substrate
NCBI Official Symbol
HGS
NCBI Official Synonym Symbols
HRS
UniProt Protein Name
Hepatocyte growth factor-regulated tyrosine kinase substrate
UniProt Synonym Protein Names
Hrs; Protein pp110
UniProt Gene Name
HGS
UniProt Synonym Gene Names
HRS
UniProt Entry Name
HGS_HUMAN
NCBI Protein Information
hepatocyte growth factor-regulated tyrosine kinase substrate; protein pp110; human growth factor-regulated tyrosine kinase substrate

NCBI Summary for HRS

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
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UniProt Comments for HRS

Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: intracellular membrane-bound organelle; early endosome membrane; cytoplasm; early endosome; cytosol; endosome; secretory granule

Molecular Function: protein domain specific binding; protein binding; metal ion binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; negative regulation of cell proliferation; protein targeting to lysosome; membrane invagination; endosome to lysosome transport; regulation of protein catabolic process; endosome transport; signal transduction; negative regulation of JAK-STAT cascade
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Research Articles on HRS

1. we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HRS antibody

 Reference Product  PubMed Publications
 EGFR antibody  >3 publications with HRS and EGFR
 TSG101 antibody  >2 publications with HRS and TSG101
 NF2 antibody  >1 publications with HRS and NF2
 EPS15 antibody  >1 publications with HRS and EPS15
 STAM antibody  >1 publications with HRS and STAM
 UBC antibody  >1 publications with HRS and UBC

Pathways associated with anti-HRS antibody

 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 ESCRT-0 Complex Pathway antibodies  ESCRT-0 Complex Pathway Diagram
 ESCRT-0 Complex Pathway antibodies  ESCRT-0 Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram

Diseases associated with anti-HRS antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >31 publications with HRS and Necrosis
 Nervous System Diseases Antibodies  >29 publications with HRS and Nervous System Diseases
 Immune System Diseases Antibodies  >24 publications with HRS and Immune System Diseases
 Inflammation Antibodies  >21 publications with HRS and Inflammation
 Liver Diseases Antibodies  >20 publications with HRS and Liver Diseases
 Kidney Diseases Antibodies  >19 publications with HRS and Kidney Diseases
 Cardiovascular Diseases Antibodies  >19 publications with HRS and Cardiovascular Diseases
 Poisoning Antibodies  >11 publications with HRS and Poisoning
 Weight Loss Antibodies  >10 publications with HRS and Weight Loss
 Heart Diseases Antibodies  >10 publications with HRS and Heart Diseases

Organs/Tissues associated with anti-HRS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >91 publications with HRS and Blood
 Muscle Antibodies  >71 publications with HRS and Muscle
 Brain Antibodies  >45 publications with HRS and Brain
 Kidney Antibodies  >31 publications with HRS and Kidney
 Liver Antibodies  >30 publications with HRS and Liver
 Bone Antibodies  >26 publications with HRS and Bone
 Nerve Antibodies  >17 publications with HRS and Nerve
 Heart Antibodies  >15 publications with HRS and Heart
 Lung Antibodies  >14 publications with HRS and Lung
 Skin Antibodies  >11 publications with HRS and Skin
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