Human ASS1 cDNA Clone Expression Plasmid – Cat# MBS1277830

ASS1 cDNA Clone – Argininosuccinate Synthetase 1 (Human)

Name: ASS1 cDNA Clone; Argininosuccinate Synthetase 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277830
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277830

MBS1277830 is a cDNA clone targeting ASS1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ASS1, cDNA Clone

Full Product Name

ASS1 cDNA Clone

Product Gene Name

ASS1 cdna clone

Sequence

atgtccagca aaggctccgt ggttctggcc tacagtggcg gcctggacac ctcgtgcatc ctcgtgtggc tgaaggaaca aggctatgac gtcattgcct atctggccaa cattggccag aaggaagact tcgaggaagc caggaagaag gcactgaagc ttggggccaa aaaggtgttc attgaggatg tcagcaggga gtttgtggag gagttcatct ggccggccat ccagtccagc gcactgtatg aggaccgcta cctcctgggc acctctcttg ccaggccctg catcgcccgc aaacaagtgg aaatcgccca gcgggagggg gccaagtatg tgtcccacgg cgccacagga aaggggaacg atcaggtccg gtttgagctc agctgctact cactggcccc ccagataaag gtcattgctc cctggaggat gcctgaattc tacaaccggt tcaagggccg caatgacctg atggagtacg caaagcaaca cgggattccc atcccggtca ctcccaagaa cccgtggagc atggatgaga acctcatgca catcagctac gaggctggaa tcctggagaa ccccaagaac caagcgcctc caggtctcta cacgaagacc caggacccag ccaaagcccc caacacccct gacattctcg agatcgagtt caaaaaaggg gtccctgtga aggtgaccaa cgtcaaggat ggcaccaccc accagacctc cttggagctc ttcatgtacc tgaacgaagt cgcgggcaag catggcgtgg gccgtattga catcgtggag aaccgcttca ttggaatgaa gtcccgaggt atctacgaga ccccagcagg caccatcctt taccatgctc atttagacat cgaggccttc accatggacc gggaagtgcg caaaatcaaa caaggcctgg gcttgaaatt tgctgagctg gtgtataccg gtttctggca cagccctgag tgtgaatttg tccgccactg catcgccaag tcccaggagc gagtggaagg gaaagtgcag gtgtccgtcc tcaagggcca ggtgtacatc ctcggccggg agtccccact gtctctctac aatgaggagc tggtgagcat gaacgtgcag ggtgattatg agccaactga tgccaccggg ttcatcaaca tcaattccct caggctgaag gaatatcatc gtctccagag caaggtcact gccaaatag

Molecular Weight

46,530 Da

OMIM

215700

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ASS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ASS1. It may not necessarily be applicable to this product.

NCBI GI #

18203821

NCBI GeneID

445

NCBI Accession #

BC021676

UniProt Secondary Accession #

Q6LDL2; Q86UZ0; Q96GT4

UniProt Related Accession #

P00966

NCBI Official Full Name

Homo sapiens argininosuccinate synthetase 1, mRNA

NCBI Official Synonym Full Names

argininosuccinate synthase 1

NCBI Official Symbol

ASS1

NCBI Official Synonym Symbols

ASS; CTLN1

UniProt Protein Name

Argininosuccinate synthase

UniProt Synonym Protein Names

Citrulline--aspartate ligase

UniProt Gene Name

ASS1

UniProt Synonym Gene Names

ASS

UniProt Entry Name

ASSY_HUMAN

NCBI Protein Information

argininosuccinate synthase

NCBI Summary for ASS1

The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2012]

UniProt Comments for ASS1

ASS1: Defects in ASS1 are the cause of citrullinemia type 1 (CTLN1). Citrullinemia belongs to the urea cycle disorders. It is an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. CTLN1 usually manifests in the first few days of life. Affected infants appear normal at birth, but as ammonia builds up in the body they present symptoms such as lethargy, poor feeding, vomiting, seizures and loss of consciousness. Less commonly, a milder CTLN1 form can develop later in childhood or adulthood. Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Endoplasmic reticulum; Ligase; Mitochondrial; EC 6.3.4.5

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytoplasm; cytosol

Molecular Function: amino acid binding; argininosuccinate synthase activity; identical protein binding; protein binding

Biological Process: arginine biosynthetic process; argininosuccinate metabolic process; aspartate metabolic process; citrulline metabolic process; positive regulation of nitric oxide biosynthetic process; urea cycle

Disease: Citrullinemia, Classic

Research Articles on ASS1

1. results show that ASS1 is elevated at the mRNA and protein levels in mesothelioma 3D spheroids and in human pleural mesotheliomas. We also have uncovered a survival role for ASS1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ASS1 cdna clone

Products by Pathway	Pathway Diagram
Alanine And Aspartate Metabolism Pathway antibodies	Alanine And Aspartate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Urea Cycle Pathway antibodies	Urea Cycle Pathway Diagram

Diseases associated with ASS1 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>16 publications with ASS1 and Nervous System Diseases
Brain Diseases Antibodies	>15 publications with ASS1 and Brain Diseases
Citrullinemia Antibodies	>14 publications with ASS1 and Citrullinemia
Cardiovascular Diseases Antibodies	>13 publications with ASS1 and Cardiovascular Diseases
Neoplasms Antibodies	>10 publications with ASS1 and Neoplasms
Heart Diseases Antibodies	>10 publications with ASS1 and Heart Diseases
Drug Toxicity Antibodies	>5 publications with ASS1 and Drug Toxicity
Heart Failure Antibodies	>5 publications with ASS1 and Heart Failure
Liver Diseases Antibodies	>3 publications with ASS1 and Liver Diseases
Ovarian Neoplasms Antibodies	>2 publications with ASS1 and Ovarian Neoplasms

Organs/Tissues associated with ASS1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with ASS1 and Blood
Heart Antibodies	>8 publications with ASS1 and Heart
Liver Antibodies	>7 publications with ASS1 and Liver
Brain Antibodies	>7 publications with ASS1 and Brain
Nerve Antibodies	>1 publications with ASS1 and Nerve
Mouth Antibodies	>1 publications with ASS1 and Mouth
Prostate Antibodies	>1 publications with ASS1 and Prostate
Stomach Antibodies	>1 publications with ASS1 and Stomach
Eye Antibodies	>1 publications with ASS1 and Eye
Muscle Antibodies	>1 publications with ASS1 and Muscle