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TANGO Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247717

MBS247717 is an antibody targeting TANGO. Also known as Rabbit Polyclonal to Human TANGO / MIA3. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TANGO / MIA3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TANGO / MIA3
Product Gene Name
anti-TANGO antibody
Product Synonym Gene Name
MIA3
Product Synonym Names
Anti-TANGO / MIA3 Antibody IHC-plus; MIA3; C219-reactive peptide; D320; KIAA0268; RP11-378J18.4; TANGO; TANGO1; UNQ6077; C219 reactive peptide; Human TANGO; MIA3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity Purified
Concentration
0.3 mg/ml (lot specific)
Specificity
Human MIA3. Predicted cross-reactivity based on amino acid sequence homology: bovine (89%).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
87,438 Da
OMIM
613455
3D Structure
ModBase 3D Structure for Q5JRA6
Target Species
Human
Immunogen Description
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 120 of MIA3.
Immunogen Type
Recombinant protein
Immunogen
TANGO / MIA3 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 120 of MIA3.
Applications Tested/Suitable for anti-TANGO antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-TANGO antibody
ICC, IF (1:100 - 1:200), IHC-P (10 ug/ml), WB (1:500 - 1:3000)

Immunohistochemistry (IHC) of anti-TANGO antibody

Anti-MIA3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-TANGO Polyclonal Antibody – Cat# MBS247717

Immunohistochemistry (IHC) of anti-TANGO antibody

Anti-MIA3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-TANGO Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247717

Immunofluorescence (IF) of anti-TANGO antibody

Immunofluorescence of methanol-fixed HepG2, using MIA3 antibody at 1:200 dilution.
Rabbit Anti-TANGO Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247717

Western Blot (WB) of anti-TANGO antibody

Sample (30 ug of whole cell lysate). A: Hela. 7.5% SDS PAGE. MIA3 antibody diluted at 1:1000.
Rabbit Anti-TANGO Polyclonal Antibody, Western Blot (WB) – Cat# MBS247717

Other Notes

Small volumes of anti-TANGO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TANGO. It may not necessarily be applicable to this product.

NCBI GI #
664806007
NCBI GeneID
375056
NCBI Accession #
NP_001287796.1
UniProt Primary Accession #
Q5JRA6
UniProt Secondary Accession #
Q14083; Q3S4X3; Q5JRA5; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; A8K2S0; A8MT05; A8MT13; B7Z430
UniProt Related Accession #
Q5JRA6
GenBank Nucleotide #
NM_001300867.1
NCBI Official Full Name
melanoma inhibitory activity protein 3 isoform 2
NCBI Official Synonym Full Names
melanoma inhibitory activity family, member 3
NCBI Official Symbol
MIA3
NCBI Official Synonym Symbols
ARNT; D320; TANGO; TANGO1; UNQ6077
UniProt Protein Name
Melanoma inhibitory activity protein 3
UniProt Synonym Protein Names
C219-reactive peptide; D320; Transport and Golgi organization protein 1
UniProt Gene Name
MIA3
UniProt Synonym Gene Names
KIAA0268; TANGO; TANGO1
UniProt Entry Name
MIA3_HUMAN
NCBI Protein Information
melanoma inhibitory activity protein 3; C219-reactive peptide; transport and Golgi organization protein 1

UniProt Comments for TANGO

MIA3: Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. Belongs to the MIA/OTOR family. Tango1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: endoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function: protein binding

Biological Process: protein transport; collagen fibril organization; exocytosis; wound healing; positive regulation of leukocyte migration; negative regulation of cell adhesion; chondrocyte development; positive regulation of bone mineralization; negative regulation of cell migration
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Research Articles on TANGO

1. TANGO expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TANGO antibody

 Disease Name  Pubmed Publications
 Coronary Artery Disease Antibodies  >4 publications with TANGO and Coronary Artery Disease
 Myocardial Infarction Antibodies  >4 publications with TANGO and Myocardial Infarction
 Atherosclerosis Antibodies  >3 publications with TANGO and Atherosclerosis
 Hypercholesterolemia Antibodies  >1 publications with TANGO and Hypercholesterolemia
 Hypertension Antibodies  >1 publications with TANGO and Hypertension

Organs/Tissues associated with anti-TANGO antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with TANGO and Blood
 Heart Antibodies  >2 publications with TANGO and Heart
 Vascular Antibodies  >1 publications with TANGO and Vascular
 Mouth Antibodies  >1 publications with TANGO and Mouth
 Bone Antibodies  >1 publications with TANGO and Bone
 Liver Antibodies  >1 publications with TANGO and Liver
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