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HNRNPC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247801

MBS247801 is an antibody targeting HNRNPC. Also known as Rabbit Polyclonal (IgG) to Human HNRNPC / HNRNP C. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Overview

Product Name
HNRNPC / HNRNP C, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human HNRNPC / HNRNP C
Product Gene Name
anti-HNRNPC antibody
Product Synonym Gene Name
HNRNPC
Product Synonym Names
Anti-HNRNPC / HNRNP C Antibody (aa241-290) IHC-plus; HNRNPC; HNRPC; HnRNP C1/C2; HNRNP; Human HNRNPC; HNRNP C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
hnRNP C1/C2 Antibody detects endogenous levels of total hnRNP C1/C2 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
27,822 Da
OMIM
164020
3D Structure
ModBase 3D Structure for P07910
Target Species
Human
Immunogen Description
Synthetic peptide from human hnRNP C1/C2 (aa241-290).
Immunogen
HNRNPC / HNRNP C antibody was raised against synthetic peptide from human hnRNP C1/C2 (aa241-290).
Antigen Modification
aa241-290
Applications Tested/Suitable for anti-HNRNPC antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-HNRNPC antibody
ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-HNRNPC antibody

Anti-HNRNPC / HNRPC antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HNRNPC Polyclonal Antibody – Cat# MBS247801

Immunofluorescence (IF) of anti-HNRNPC antibody

Immunofluorescence of HUVEC cells, using hnRNP C1/C2 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-HNRNPC Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247801

Western Blot (WB) of anti-HNRNPC antibody

Western blot of extracts from HepG2/COLO205 cells, using hnRNP C1/C2 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-HNRNPC Polyclonal Antibody, Western Blot (WB) – Cat# MBS247801

Other Notes

Small volumes of anti-HNRNPC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HNRNPC. It may not necessarily be applicable to this product.

NCBI GI #
117190174
NCBI GeneID
3183
NCBI Accession #
NP_004491.2
UniProt Primary Accession #
P07910
UniProt Secondary Accession #
P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; D3DS19; D3DS22
UniProt Related Accession #
P07910
GenBank Nucleotide #
NM_004500.3
NCBI Official Full Name
heterogeneous nuclear ribonucleoproteins C1/C2 isoform b
NCBI Official Synonym Full Names
heterogeneous nuclear ribonucleoprotein C (C1/C2)
NCBI Official Symbol
HNRNPC
NCBI Official Synonym Symbols
C1; C2; HNRNP; HNRPC; SNRPC
UniProt Protein Name
Heterogeneous nuclear ribonucleoproteins C1/C2
Protein Family
Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name
HNRNPC
UniProt Synonym Gene Names
HNRPC; hnRNP C1/C2
UniProt Entry Name
HNRPC_HUMAN
NCBI Protein Information
heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein

NCBI Summary for HNRNPC

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for HNRNPC

hnRNP C1/C2: a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described.

Protein type: RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; spliceosome; protein complex; membrane; nuclear chromatin; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; nucleosomal DNA binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; poly(U) binding

Biological Process: osteoblast differentiation; nuclear mRNA splicing, via spliceosome; RNA splicing; ATP-dependent chromatin remodeling; gene expression
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Research Articles on HNRNPC

1. PTBP1 and hnRNP C repress exon 3 inclusion, and that downregulation of PTBP1 inhibited BIM-mediated apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HNRNPC antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-HNRNPC antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with HNRNPC and Carcinoma
 Lung Diseases Antibodies  >3 publications with HNRNPC and Lung Diseases
 Breast Neoplasms Antibodies  >2 publications with HNRNPC and Breast Neoplasms
 Inflammation Antibodies  >2 publications with HNRNPC and Inflammation
 Chromosome Aberrations Antibodies  >1 publications with HNRNPC and Chromosome Aberrations
 Carcinoma, Hepatocellular Antibodies  >1 publications with HNRNPC and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with HNRNPC and Cardiovascular Diseases
 Weight Loss Antibodies  >1 publications with HNRNPC and Weight Loss
 Disease Models, Animal Antibodies  >1 publications with HNRNPC and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with HNRNPC and Neoplasms, Experimental

Organs/Tissues associated with anti-HNRNPC antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with HNRNPC and Lung
 Liver Antibodies  >5 publications with HNRNPC and Liver
 Brain Antibodies  >4 publications with HNRNPC and Brain
 Ovary Antibodies  >2 publications with HNRNPC and Ovary
 Kidney Antibodies  >2 publications with HNRNPC and Kidney
 Embryonic Tissue Antibodies  >2 publications with HNRNPC and Embryonic Tissue
 Nerve Antibodies  >2 publications with HNRNPC and Nerve
 Bone Antibodies  >1 publications with HNRNPC and Bone
 Lymph Antibodies  >1 publications with HNRNPC and Lymph
 Blood Antibodies  >1 publications with HNRNPC and Blood
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