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CIRP Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247810

MBS247810 is an antibody targeting CIRP. Also known as Goat Polyclonal to Human CIRP / CIRBP. Reactive in Bat, Dog, Hamster, Human, Monkey, Mouse, Orangutan, Pig, Rat. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CIRP / CIRBP, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human CIRP / CIRBP
Product Gene Name
Product Synonym Gene Name
CIRBP
Product Synonym Names
Anti-CIRP / CIRBP Antibody (aa161-172) IHC-plus; CIRBP; A18 hnRNP; A18HNRNP; CIRP; Human CIRP; CIRBP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Dog, Hamster, Human, Monkey, Mouse, Orangutan, Pig, Rat
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CIRBP.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
26,130 Da
OMIM
602649
3D Structure
ModBase 3D Structure for Q14011
Target Species
Human
Immunogen Description
Synthetic peptide C-RDSYDSYATHNE from the C-terminus of human CIRBP (NP_001271.1). Percent identity by BLAST analysis: Human, Orangutan, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Dog, Bat, Pig, Opossum, Platypus (100%); Turkey (92%).
Immunogen Type
Synthetic peptide
Immunogen
CIRP / CIRBP antibody was raised against synthetic peptide C-RDSYDSYATHNE from the C-terminus of human CIRBP (NP_001271.1). Percent identity by BLAST analysis: Human, Orangutan, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Dog, Bat, Pig, Opossum, Platypus (100%); Turkey (92%); Xenopus, Trout (83%).
Antigen Modification
aa161-172
Applications Tested/Suitable for anti-CIRP antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CIRP antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.01 - 0.03 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 18kD band observed in Mouse and Rat Testis lysates (calculated MW of 18.6kD according to Human NP_001271.1 and Mouse NP_031731.1). Recommended concentration: 0.01-0.03 ug/ml.

Immunohistochemistry (IHC) of anti-CIRP antibody

Anti-CIRP / CIRBP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
Goat Anti-CIRP Polyclonal Antibody – Cat# MBS247810

Western Blot (WB) of anti-CIRP antibody

CIRBP antibody (0.01 ug/ml) staining of Mouse Testis lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-CIRP Polyclonal Antibody, Western Blot (WB) – Cat# MBS247810

Other Notes

Small volumes of anti-CIRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CIRP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cold-inducible RNA-binding protein isoform 1
NCBI Official Synonym Full Names
cold inducible RNA binding protein
NCBI Official Symbol
CIRBP
NCBI Official Synonym Symbols
CIRP
UniProt Protein Name
Cold-inducible RNA-binding protein
UniProt Synonym Protein Names
A18 hnRNP; Glycine-rich RNA-binding protein CIRP
UniProt Gene Name
CIRBP
UniProt Synonym Gene Names
A18HNRNP; CIRP
UniProt Entry Name
CIRBP_HUMAN
NCBI Protein Information
cold-inducible RNA-binding protein; A18 hnRNP; glycine-rich RNA binding protein; cold inducible RNA-binding protein

UniProt Comments for CIRP

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (). Promotes assembly of stress granules (SGs), when overexpressed.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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