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SLC47A2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248219

MBS248219 is an antibody targeting SLC47A2. Also known as Goat Polyclonal to Human SLC47A2. Reactive in Gorilla, Human. Host: Goat. More details

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Product Overview

Product Name
SLC47A2, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human SLC47A2
Product Gene Name
anti-SLC47A2 antibody
Product Synonym Names
Anti-SLC47A2 Antibody (C-Terminus) IHC-plus; SLC47A2; MATE2; MATE2-K; H+/organic cation antiporter; HMATE-2; MATE-2; MATE2-B; MATE2K; Human SLC47A2
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gorilla, Human
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human SLC47A2. This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
23,344 Da
OMIM
609833
3D Structure
ModBase 3D Structure for Q86VL8
Target Species
Human
Immunogen Description
Synthetic peptide SECHVDFFRTPEEAH from an internal region (near C-terminus) of human SLC47A2 (NP_690872.2; NP_001093116.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Chimpanzee, Orangutan (93%); Gibbon, Monkey, Marmoset (87%).
Immunogen Type
Synthetic peptide
Immunogen
SLC47A2 antibody was raised against synthetic peptide SECHVDFFRTPEEAH from an internal region (near C-terminus) of human SLC47A2 (NP_690872.2; NP_001093116.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Chimpanzee, Orangutan (93%); Gibbon, Monkey, Marmoset (87%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-SLC47A2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC47A2 antibody
ELISA (1:32000), IHC-P (5 ug/ml), WB (0.1 - 1 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 60kD band observed in Human Testis lysates (calculated MW of 61.0kD according to NP_001093116.1). Recommended concentration: 0.1-1 ug/ml.

Immunohistochemistry (IHC) of anti-SLC47A2 antibody

Human, Kidney: Formalin-Fixed Paraffin-Embedded (FFPE)
Goat Anti-SLC47A2 Polyclonal Antibody – Cat# MBS248219

Western Blot (WB) of anti-SLC47A2 antibody

SLC47A2 antibody (0.3 ug/ml) staining of Human Testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SLC47A2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248219

Other Notes

Small volumes of anti-SLC47A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC47A2. It may not necessarily be applicable to this product.

NCBI GI #
153792564
NCBI GeneID
146802
NCBI Accession #
NP_001093116.1
UniProt Primary Accession #
Q86VL8
UniProt Secondary Accession #
Q63HJ9; Q8IV44; Q96NA1; A0JBX9; A0P8Z7
UniProt Related Accession #
Q86VL8
GenBank Nucleotide #
NM_001099646.1
NCBI Official Full Name
multidrug and toxin extrusion protein 2 isoform 2
NCBI Official Synonym Full Names
solute carrier family 47 (multidrug and toxin extrusion), member 2
NCBI Official Symbol
SLC47A2
NCBI Official Synonym Symbols
MATE2; MATE2K; MATE2-B; MATE2-K
UniProt Protein Name
Multidrug and toxin extrusion protein 2
UniProt Synonym Protein Names
Kidney-specific H(+)/organic cation antiporter; Solute carrier family 47 member 2
Protein Family
Multidrug and toxin extrusion protein
UniProt Gene Name
SLC47A2
UniProt Synonym Gene Names
MATE2; MATE-2; hMATE-2
UniProt Entry Name
S47A2_HUMAN
NCBI Protein Information
multidrug and toxin extrusion protein 2; MATE-2; hMATE-2; H+/organic cation antiporter; multidrug and toxin extrusion 2; solute carrier family 47, member 2; kidney-specific H(+)/organic cation antiporter

NCBI Summary for SLC47A2

This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for SLC47A2

SLC47A2: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: plasma membrane; integral to membrane

Molecular Function: drug transporter activity; antiporter activity

Biological Process: multidrug transport; transmembrane transport
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Research Articles on SLC47A2

1. The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC47A2 antibody

 Reference Product  PubMed Publications
 SLC22A2 antibody  >4 publications with SLC47A2 and SLC22A2

Pathways associated with anti-SLC47A2 antibody

 Products by Pathway  Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC47A2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with SLC47A2 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with SLC47A2 and Kidney Diseases

Organs/Tissues associated with anti-SLC47A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >8 publications with SLC47A2 and Kidney
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