Human TXNRD1 cDNA Clone Expression Plasmid – Cat# MBS1270025

TXNRD1 cDNA Clone – Thioredoxin Reductase 1 (Human)

Name: TXNRD1 cDNA Clone; Thioredoxin Reductase 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270025
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270025

MBS1270025 is a cDNA clone targeting TXNRD1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TXNRD1, cDNA Clone

Full Product Name

TXNRD1 cDNA Clone

Product Gene Name

TXNRD1 cdna clone

Sequence

atgaacggcc ctgaagatct tcccaagtcc tatgactatg accttatcat cattggaggt ggctcaggag gtctggcagc tgctaaggag gcagcccaat atggcaagaa ggtgatggtc ctggactttg tcactcccac ccctcttgga actagatggg gtcttggagg aacatgtgtg aatgtgggtt gcatacctaa aaaactgatg catcaagcag ctttgttagg acaagccctg caagactctc gaaattatgg atggaaagtc gaggagacag ttaagcatga ttgggacaga atgatagaag ctgtacagaa tcacattggc tctttgaatt ggggctaccg agtagctctg cgggagaaaa aagtcgtcta tgagaatgct tatgggcaat ttattggtcc tcacaggatt aaggcaacaa ataataaagg caaagaaaaa atttattcag cagagagatt tctcattgcc actggtgaaa gaccacgtta cttgggcatc cctggtgaca aagaatactg catcagcagt gatgatcttt tctccttgcc ttactgcccg ggtaagaccc tggttgttgg agcatcctat gtcgctttgg agtgcgctgg atttcttgct ggtattggtt tagacgtcac tgttatggtt aggtccattc ttcttagagg atttgaccag gacatggcca acaaaattgg tgaacacatg gaagaacatg gcatcaagtt tataagacag ttcgtaccaa ttaaagttga acaaattgaa gcagggacac caggccgact cagagtagta gctcagtcca ccaatagtga ggaaatcatt gaaggagaat ataatacggt gatgctggca ataggaagag atgcttgcac aagaaaaatt ggcttagaaa ccgtaggggt gaagataaat gaaaagactg gaaaaatacc tgtcacagat gaagaacaga ccaatgtgcc ttacatctat gccattggcg atatattgga ggataaggtg gagctcaccc cagttgcaat ccaggcagga agattgctgg ctcagaggct ctatgcaggt tccactgtca agtgtgacta tgaaaatgtt ccaaccactg tatttactcc tttggaatat ggtgcttgtg gcctttctga ggagaaagct gtggagaagt ttggggaaga aaatattgag gtttaccata gttacttttg gccattggaa tggacgattc cgtcaagaga taacaacaaa tgttatgcaa aaataatctg taatactaaa gacaatgaac gtgttgtggg ctttcacgta ctgggtccaa atgctggaga agttacacaa ggctttgcag ctgcgctcaa atgtggactg accaaaaagc agctggacag cacaattgga atccaccctg tctgtgcaga ggtattcaca acattgtctg tgaccaagcg ctctggggca agcatcctcc aggctggctg ctgaggttaa

Molecular Weight

50,873 Da

OMIM

601112

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TXNRD1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TXNRD1. It may not necessarily be applicable to this product.

NCBI GI #

17390271

NCBI GeneID

7296

NCBI Accession #

BC018122

UniProt Secondary Accession #

Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780

UniProt Related Accession #

Q16881

NCBI Official Full Name

Homo sapiens thioredoxin reductase 1, mRNA

NCBI Official Synonym Full Names

thioredoxin reductase 1

NCBI Official Symbol

TXNRD1

NCBI Official Synonym Symbols

TR; TR1; TXNR; TRXR1; GRIM-12

UniProt Protein Name

Thioredoxin reductase 1, cytoplasmic

UniProt Synonym Protein Names

Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1

Protein Family

Thioredoxin reductase

UniProt Gene Name

TXNRD1

UniProt Synonym Gene Names

GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein

UniProt Entry Name

TRXR1_HUMAN

NCBI Protein Information

thioredoxin reductase 1, cytoplasmic

NCBI Summary for TXNRD1

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for TXNRD1

TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.

Protein type: Nuclear receptor co-regulator; Oxidoreductase; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: cytosol

Molecular Function: protein binding; thioredoxin-disulfide reductase activity

Biological Process: nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species; selenium metabolic process

Research Articles on TXNRD1

1. Tissue microarrays containing human nevi and melanomas were used to evaluate levels of the antioxidant protein thioredoxin reductase 1 (TR1), which was found to increase as a function of disease progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TXNRD1 cdna clone

Products by Pathway	Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Oxidative Stress Pathway antibodies	Oxidative Stress Pathway Diagram
PPARA Activates Gene Expression Pathway antibodies	PPARA Activates Gene Expression Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram

Diseases associated with TXNRD1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>49 publications with TXNRD1 and Neoplasms
Drug Toxicity Antibodies	>19 publications with TXNRD1 and Drug Toxicity
Liver Diseases Antibodies	>13 publications with TXNRD1 and Liver Diseases
Neoplasms, Experimental Antibodies	>11 publications with TXNRD1 and Neoplasms, Experimental
Liver Neoplasms Antibodies	>10 publications with TXNRD1 and Liver Neoplasms
Cardiovascular Diseases Antibodies	>9 publications with TXNRD1 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>9 publications with TXNRD1 and Breast Neoplasms
Nervous System Diseases Antibodies	>9 publications with TXNRD1 and Nervous System Diseases
Liver Neoplasms, Experimental Antibodies	>6 publications with TXNRD1 and Liver Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>6 publications with TXNRD1 and Cell Transformation, Neoplastic

Organs/Tissues associated with TXNRD1 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>37 publications with TXNRD1 and Liver
Lung Antibodies	>13 publications with TXNRD1 and Lung
Blood Antibodies	>13 publications with TXNRD1 and Blood
Kidney Antibodies	>11 publications with TXNRD1 and Kidney
Muscle Antibodies	>11 publications with TXNRD1 and Muscle
Heart Antibodies	>10 publications with TXNRD1 and Heart
Prostate Antibodies	>8 publications with TXNRD1 and Prostate
Brain Antibodies	>8 publications with TXNRD1 and Brain
Skin Antibodies	>7 publications with TXNRD1 and Skin
Testis Antibodies	>7 publications with TXNRD1 and Testis