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BMF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248381

Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad,… More details

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Product Overview

Product Name
BMF, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human BMF
Product Gene Name
Product Synonym Names
Anti-BMF Antibody IHC-plus; BMF; Bcl2 modifying factor; Bcl-2-modifying factor; Human BMF
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 30% glycerol, 0.5% BSA, 0.01% Thimerosal
Purity/Purification
Affinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human BMF
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
14,150 Da
OMIM
606266
3D Structure
ModBase 3D Structure for Q96LC9
Target Species
Human
Immunogen Description
Synthetic peptide surrounding amino acid 9 of human BMF
Immunogen Type
Synthetic peptide

Product Categories/Family for anti-BMF antibody

Applications Tested/Suitable for anti-BMF antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-BMF antibody
IHC-P (5 ug/ml), WB (0.5 - 4 ug/ml)

Immunohistochemistry (IHC) of anti-BMF antibody

Anti-BMF antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-BMF Polyclonal Antibody – Cat# MBS248381

Other Notes

Small volumes of anti-BMF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMF purchase

MBS248381 is an antibody targeting BMF. Also known as Rabbit Polyclonal (IgG) to Human BMF. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BMF. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bcl-2-modifying factor isoform bmf-1
NCBI Official Synonym Full Names
Bcl2 modifying factor
NCBI Official Symbol
BMF
UniProt Protein Name
Bcl-2-modifying factor
UniProt Gene Name
BMF
UniProt Entry Name
BMF_HUMAN
NCBI Protein Information
bcl-2-modifying factor

NCBI Summary for BMF

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for BMF

BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Apoptosis

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: mitochondrial outer membrane; acrosome; plasma membrane; cytosol; myosin complex

Molecular Function: protein binding

Biological Process: positive regulation of protein homooligomerization; apoptosis; anoikis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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