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SDCCAG8 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248554

MBS248554 is an antibody targeting SDCCAG8. Also known as Goat Polyclonal to Human SDCCAG8. Reactive in Chimpanzee, Gorilla, Human. Host: Goat. More details

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Product Overview

Product Name
SDCCAG8, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human SDCCAG8
Product Gene Name
anti-SDCCAG8 antibody
Product Synonym Names
Anti-SDCCAG8 Antibody (Internal) IHC-plus; SDCCAG8; Antigen NY-CO-8; CCCAP; CCCAP SLSN7; HCCCAP; NPHP10; NY-CO-8; HSPC085; SLSN7; BBS16; Human SDCCAG8
Clonality
Polyclonal
Host
Goat
Species Reactivity
Chimpanzee, Gorilla, Human
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human SDCCAG8.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
78,021 Da
OMIM
gene 613615
3D Structure
ModBase 3D Structure for Q86SQ7
Target Species
Human
Immunogen Description
Synthetic peptide C-TINDQSQYIHHLEAE from an internal region of human SDCCAG8 (NP_006633.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%).
Immunogen Type
Synthetic peptide
Immunogen
SDCCAG8 antibody was raised against synthetic peptide C-TINDQSQYIHHLEAE from an internal region of human SDCCAG8 (NP_006633.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Monkey, Galago, Mouse, Rat, Elephant, Dog, Horse, Rabbit, Porcine, Opossum, Guinea pig (93%); Orangutan, Marmoset, Bovine, Bat, Turkey, Chicken, Platypus, Lizard (87%); Zebra finch, Xenopus (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-SDCCAG8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SDCCAG8 antibody
ELISA (1:128000), IHC-P (5 ug/ml), WB (0.3 - 1 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 80kD band observed in lysates of cell line HepG2 (calculated MW of 82.7kD according to NP_006633.1). Recommended concentration: 0.3-1 ug/ml.

Immunohistochemistry (IHC) of anti-SDCCAG8 antibody

Anti-SDCCAG8 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-SDCCAG8 Polyclonal Antibody – Cat# MBS248554

Western Blot (WB) of anti-SDCCAG8 antibody

SDCCAG8 antibody (0.3 ug/ml) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SDCCAG8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248554

Other Notes

Small volumes of anti-SDCCAG8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SDCCAG8. It may not necessarily be applicable to this product.

NCBI GI #
28269672
NCBI GeneID
10806
NCBI Accession #
NP_006633.1
UniProt Primary Accession #
Q86SQ7
UniProt Secondary Accession #
O60527; Q3ZCR6; Q8N5F2; Q9P0F1
UniProt Related Accession #
Q86SQ7
GenBank Nucleotide #
NM_006642.3
NCBI Official Full Name
serologically defined colon cancer antigen 8
NCBI Official Synonym Full Names
serologically defined colon cancer antigen 8
NCBI Official Symbol
SDCCAG8
NCBI Official Synonym Symbols
BBS16; CCCAP; SLSN7; NPHP10; hCCCAP; HSPC085; NY-CO-8; CCCAP SLSN7
UniProt Protein Name
Serologically defined colon cancer antigen 8
UniProt Synonym Protein Names
Antigen NY-CO-8; Centrosomal colon cancer autoantigen protein; hCCCAP
Protein Family
Serologically defined colon cancer antigen
UniProt Gene Name
SDCCAG8
UniProt Synonym Gene Names
CCCAP; NPHP10; hCCCAP
UniProt Entry Name
SDCG8_HUMAN
NCBI Protein Information
serologically defined colon cancer antigen 8; antigen NY-CO-8; centrosomal colon cancer autoantigen protein

NCBI Summary for SDCCAG8

This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]

UniProt Comments for SDCCAG8

SDCCAG8: Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis. Defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7 (SLSN7). SLSN7 is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: centriole; centrosome; intercellular junction; cytosol

Molecular Function: protein binding

Biological Process: establishment of cell polarity; organelle organization and biogenesis; lumen formation; mitotic cell cycle; G2/M transition of mitotic cell cycle

Disease: Bardet-biedl Syndrome 16; Bardet-biedl Syndrome 1; Senior-loken Syndrome 7
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Research Articles on SDCCAG8

1. significant associations in schizophrenia to SDCAAG8 and extensive replication of associations reported by the Schizophrenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SDCCAG8 antibody

 Reference Product  PubMed Publications
 CEP290 antibody  >2 publications with SDCCAG8 and CEP290
 OFD1 antibody  >2 publications with SDCCAG8 and OFD1
 CETN2 antibody  >1 publications with SDCCAG8 and CETN2
 ALMS1 antibody  >1 publications with SDCCAG8 and ALMS1

Pathways associated with anti-SDCCAG8 antibody

 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with anti-SDCCAG8 antibody

 Disease Name  Pubmed Publications
 Retinal Diseases Antibodies  >6 publications with SDCCAG8 and Retinal Diseases
 Congenital Abnormalities Antibodies  >4 publications with SDCCAG8 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >4 publications with SDCCAG8 and Nervous System Diseases
 Kidney Diseases Antibodies  >4 publications with SDCCAG8 and Kidney Diseases
 Brain Diseases Antibodies  >3 publications with SDCCAG8 and Brain Diseases
 Fatty Liver, Alcoholic Antibodies  >1 publications with SDCCAG8 and Fatty Liver, Alcoholic
 Liver Diseases Antibodies  >1 publications with SDCCAG8 and Liver Diseases
 Non-alcoholic Fatty Liver Disease Antibodies  >1 publications with SDCCAG8 and Non-alcoholic Fatty Liver Disease
 Fatty Liver Antibodies  >1 publications with SDCCAG8 and Fatty Liver
 Kidney Diseases, Cystic Antibodies  >1 publications with SDCCAG8 and Kidney Diseases, Cystic

Organs/Tissues associated with anti-SDCCAG8 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6 publications with SDCCAG8 and Kidney
 Eye Antibodies  >4 publications with SDCCAG8 and Eye
 Blood Antibodies  >2 publications with SDCCAG8 and Blood
 Brain Antibodies  >2 publications with SDCCAG8 and Brain
 Mammary Gland Antibodies  >1 publications with SDCCAG8 and Mammary Gland
 Liver Antibodies  >1 publications with SDCCAG8 and Liver
 Prostate Antibodies  >1 publications with SDCCAG8 and Prostate
 Embryonic Tissue Antibodies  >1 publications with SDCCAG8 and Embryonic Tissue
 Lung Antibodies  >1 publications with SDCCAG8 and Lung
 Testis Antibodies  >1 publications with SDCCAG8 and Testis
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