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ZMYND8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248629

MBS248629 is an antibody targeting ZMYND8. Also known as Rabbit Polyclonal (IgG) to Human ZMYND8 / RACK7. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ZMYND8 / RACK7, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human ZMYND8 / RACK7
Product Gene Name
anti-ZMYND8 antibody
Product Synonym Gene Name
RACK7
Product Synonym Names
Anti-ZMYND8 / RACK7 Antibody (aa581-630) IHC-plus; ZMYND8; CTCL-associated antigen se14-3; CTCL tumor antigen se14-3; KIAA1125; Predicted protein of HQ2893; PRO2893; PRKCBP1; RACK7; Human ZMYND8; RACK7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
PKCB1 Antibody detects endogenous levels of total PKCB1 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
122,116 Da
3D Structure
ModBase 3D Structure for Q9ULU4
Target Species
Human
Immunogen Description
Synthetic peptide from human PKCB1 (aa581-630).
Immunogen
ZMYND8 / RACK7 antibody was raised against synthetic peptide from human PKCB1 (aa581-630).
Antigen Modification
aa581-630
Applications Tested/Suitable for anti-ZMYND8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ZMYND8 antibody
ELISA (1:1000), IHC-P (20 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-ZMYND8 antibody

Human, Breast: Formalin-Fixed Paraffin-Embedded (FFPE)
Rabbit Anti-ZMYND8 Polyclonal Antibody – Cat# MBS248629

Western Blot (WB) of anti-ZMYND8 antibody

Western blot of extracts from 293 cells, using PKCB1 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-ZMYND8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248629

Other Notes

Small volumes of anti-ZMYND8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZMYND8. It may not necessarily be applicable to this product.

NCBI GI #
34335266
NCBI GeneID
23613
NCBI Accession #
NP_036540.3
UniProt Primary Accession #
Q9ULU4
UniProt Secondary Accession #
Q13517; Q2HXV1; B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; J3KPU3
UniProt Related Accession #
Q9ULU4
GenBank Nucleotide #
NM_012408.5
NCBI Official Full Name
protein kinase C-binding protein 1 isoform b
NCBI Official Synonym Full Names
zinc finger, MYND-type containing 8
NCBI Official Symbol
ZMYND8
NCBI Official Synonym Symbols
RACK7; PRKCBP1; PRO2893
UniProt Protein Name
Protein kinase C-binding protein 1
UniProt Synonym Protein Names
Cutaneous T-cell lymphoma-associated antigen se14-3; CTCL-associated antigen se14-3; Rack7; Zinc finger MYND domain-containing protein 8
Protein Family
Protein kinase C-binding protein
UniProt Gene Name
ZMYND8
UniProt Synonym Gene Names
KIAA1125; PRKCBP1; RACK7; CTCL-associated antigen se14-3
UniProt Entry Name
PKCB1_HUMAN
NCBI Protein Information
protein kinase C-binding protein 1; CTCL tumor antigen se14-3; predicted protein of HQ2893; zinc finger MYND domain-containing protein 8; cutaneous T-cell lymphoma-associated antigen se14-3

NCBI Summary for ZMYND8

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ZMYND8

RACK7: a DNA damage response (DDR) protein, receptor for activated C-kinase (RACK) protein, and a transcriptional regulator. A bromodomain (BRD)-containing protein that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromatin. Targets DNA damage within actively transcribed regions, repressing transcription, and promoting repair by homologous recombination. A cutaneous T-cell lymphoma-associated antigen that contains a bromodomain and two zinc fingers. Twenty-two alternatively spliced isoforms of the human protein hve been reported. Note: This description may include information from UniProtKB

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: nucleus

Molecular Function: protein binding; zinc ion binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter
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Research Articles on ZMYND8

1. ZMYND8 induces vegfa mRNA expression selectively in prostate cancer xenografts.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ZMYND8 antibody

 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with anti-ZMYND8 antibody

 Disease Name  Pubmed Publications
 Uterine Cervical Neoplasms Antibodies  >1 publications with ZMYND8 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-ZMYND8 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with ZMYND8 and Bone Marrow
 Bone Antibodies  >1 publications with ZMYND8 and Bone
 Prostate Antibodies  >1 publications with ZMYND8 and Prostate
 Vascular Antibodies  >1 publications with ZMYND8 and Vascular
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