VAMP7 Antibody – Rabbit Polyclonal

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; neuron projection; cell surface; intracellular membrane-bound organelle; lysosomal membrane; late endosome membrane; secretory granule membrane; integral to membrane; phagocytic vesicle; trans-Golgi network; pseudopodium; secretory granule; SNARE complex; phagocytic vesicle membrane; membrane; lamellipodium; apical part of cell; perinuclear region of cytoplasm; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: SNAP receptor activity; SNARE binding; protein binding; syntaxin binding

Biological Process: ER to Golgi vesicle-mediated transport; exocytosis; autophagic vacuole fusion; natural killer cell degranulation; neutrophil degranulation; vesicle fusion with Golgi apparatus; endocytosis; calcium ion-dependent exocytosis; vesicle-mediated transport; vesicle fusion; Golgi to plasma membrane protein transport; endosome to lysosome transport; eosinophil degranulation; post-Golgi vesicle-mediated transport; triacylglycerol transport; phagocytosis, engulfment