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KCNJ16 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248683

MBS248683 is an antibody targeting KCNJ16. Also known as Rabbit Polyclonal (IgG) to Mouse KCNJ16 / Kir5.1. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Overview

Product Name
KCNJ16 / Kir5.1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Mouse KCNJ16 / Kir5.1
Product Gene Name
anti-KCNJ16 antibody
Product Synonym Gene Name
Kir5.1
Product Synonym Names
Anti-KCNJ16 / Kir5.1 Antibody (aa369-418) IHC-plus; KCNJ16; BIR9; KIR5.1; Mouse KCNJ16; Kir5.1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Kir5.1 Antibody detects endogenous levels of total Kir5.1 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
47,949 Da
OMIM
605722
3D Structure
ModBase 3D Structure for Q9NPI9
Target Species
Mouse
Immunogen Description
Synthetic peptide from mouse Kir5.1 (aa369-418).
Immunogen
KCNJ16 / Kir5.1 antibody was raised against synthetic peptide from mouse Kir5.1 (aa369-418).
Antigen Modification
aa369-418

Product Categories/Family for anti-KCNJ16 antibody

Family: Ion Channel; Subfamily: Potassium channel - inward-rectifying
Applications Tested/Suitable for anti-KCNJ16 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-KCNJ16 antibody
ELISA (1:10000), IF (1:100 - 1:500), IHC-P (20 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-KCNJ16 antibody

Anti-KCNJ16 / KIR5.1 antibody IHC staining of human ganglion cells (prostate). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Rabbit Anti-KCNJ16 Polyclonal Antibody – Cat# MBS248683

Immunohistochemistry (IHC) of anti-KCNJ16 antibody

IHC of paraffin-embedded human brain tissue, using Kir5.1 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-KCNJ16 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS248683

Immunofluorescence (IF) of anti-KCNJ16 antibody

Immunofluorescence of HeLa cells, using Kir5.1 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-KCNJ16 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248683

Western Blot (WB) of anti-KCNJ16 antibody

Western blot of extracts from HeLa cells, using Kir5.1 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-KCNJ16 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248683

Other Notes

Small volumes of anti-KCNJ16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNJ16. It may not necessarily be applicable to this product.

NCBI GI #
8923823
NCBI GeneID
3773
NCBI Accession #
NP_061128.1
UniProt Primary Accession #
Q9NPI9
UniProt Related Accession #
Q9NPI9
GenBank Nucleotide #
NM_018658.2
NCBI Official Full Name
inward rectifier potassium channel 16
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 16
NCBI Official Symbol
KCNJ16
NCBI Official Synonym Symbols
BIR9; KIR5.1
UniProt Protein Name
Inward rectifier potassium channel 16
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir5.1; Potassium channel, inwardly rectifying subfamily J member 16
Protein Family
Inward rectifier potassium channel
UniProt Gene Name
KCNJ16
UniProt Entry Name
KCJ16_HUMAN
NCBI Protein Information
inward rectifier potassium channel 16; inward rectifier K+ channel KIR5.1; inward rectifier K(+) channel Kir5.1; potassium channel, inwardly rectifying subfamily J member 16

NCBI Summary for KCNJ16

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
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UniProt Comments for KCNJ16

Kir5.1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane

Molecular Function: inward rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion import; potassium ion transport
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Research Articles on KCNJ16

1. study provides an explanation for the pathophysiology of the p.A167V KCNJ10 mutation, which had not been considered pathogenic on its own; findings provide evidence for functional cooperation of KCNJ10 and KCNJ16; in vitro ascertainment of KCNJ10 function may necessitate co-expression with KCNJ16

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNJ16 antibody

 Reference Product  PubMed Publications
 KCNJ10 antibody  >6 publications with KCNJ16 and KCNJ10
 KCNJ2 antibody  >2 publications with KCNJ16 and KCNJ2

Pathways associated with anti-KCNJ16 antibody

 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with anti-KCNJ16 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with KCNJ16 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with KCNJ16 and Brain Diseases
 Carcinoma Antibodies  >2 publications with KCNJ16 and Carcinoma
 Hypertension Antibodies  >1 publications with KCNJ16 and Hypertension
 Adenocarcinoma Antibodies  >1 publications with KCNJ16 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with KCNJ16 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with KCNJ16 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with KCNJ16 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-KCNJ16 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >7 publications with KCNJ16 and Kidney
 Brain Antibodies  >4 publications with KCNJ16 and Brain
 Ear Antibodies  >1 publications with KCNJ16 and Ear
 Liver Antibodies  >1 publications with KCNJ16 and Liver
 Nerve Antibodies  >1 publications with KCNJ16 and Nerve
 Pancreas Antibodies  >1 publications with KCNJ16 and Pancreas
 Thyroid Antibodies  >1 publications with KCNJ16 and Thyroid
 Parathyroid Antibodies  >1 publications with KCNJ16 and Parathyroid
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