DHX36 Antibody – Rabbit Polyclonal

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

DHX36: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Helicase; EC 3.6.4.13; EC 3.6.4.12; RNA-binding

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: chromosome, telomeric region; cytoplasm; nucleus; cytosol

Molecular Function: G-quadruplex DNA binding; DNA-dependent ATPase activity; protein binding; histone deacetylase binding; double-stranded RNA binding; ATP-dependent RNA helicase activity; ATP binding

Biological Process: RNA processing; ossification; response to exogenous dsRNA; transcription, DNA-dependent; RNA secondary structure unwinding; response to virus; positive regulation of telomere maintenance; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter