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UQCRC1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249008

MBS249008 is an antibody targeting UQCRC1. Also known as Mouse Monoclonal [clone 1G6] (IgG1) to Human UQCRC1. Reactive in Dog, Human, Monkey, Mouse, Rat. Host: Mouse. More details

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Product Overview

Product Name
UQCRC1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 1G6] (IgG1) to Human UQCRC1
Product Gene Name
anti-UQCRC1 antibody
Product Synonym Names
Anti-UQCRC1 Antibody (clone 1G6) IHC-plus; UQCRC1; Complex III subunit 1; D3S3191; Core protein I; QCR1; UQCR1; Human UQCRC1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1G6
Host
Mouse
Species Reactivity
Dog, Human, Monkey, Mouse, Rat
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Protein A/G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human UQCRC1
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
52,646 Da
OMIM
191328
3D Structure
ModBase 3D Structure for P31930
Target Species
Human
Immunogen Description
Human recombinant protein fragment corresponding to amino acids 46-305 of human UQCRC1 (NP_003356) produced in E Coli.
Immunogen Type
Recombinant protein
Immunogen
UQCRC1 antibody was raised against human recombinant protein fragment corresponding to amino acids 46-305 of human UQCRC1 (NP_003356) produced in E Coli.

Product Categories/Family for anti-UQCRC1 antibody

Family: Protease; Subfamily: Metallopeptidase M16
Applications Tested/Suitable for anti-UQCRC1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-UQCRC1 antibody
Flo (1:100), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-UQCRC1 antibody

Anti-UQCRC1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-UQCRC1 Monoclonal Antibody – Cat# MBS249008

Immunohistochemistry (IHC) of anti-UQCRC1 antibody

Anti-UQCRC1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Mouse Anti-UQCRC1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS249008

Flow Cytometry (FC/FACS) of anti-UQCRC1 antibody

HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-UQCRC1 antibody, and then analyzed by flow cytometry.
Mouse Anti-UQCRC1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS249008

Western Blot (WB) of anti-UQCRC1 antibody

Western blot of extracts (35 ug) from 9 different cell lines by using g anti-UQCRC1 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
Mouse Anti-UQCRC1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249008

Western Blot (WB) of anti-UQCRC1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY UQCRC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-UQCRC1.
Mouse Anti-UQCRC1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249008

Other Notes

Small volumes of anti-UQCRC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UQCRC1. It may not necessarily be applicable to this product.

NCBI GI #
46593007
NCBI GeneID
7384
NCBI Accession #
NP_003356.2
UniProt Primary Accession #
P31930
UniProt Secondary Accession #
Q96DD2; B2R7R8
UniProt Related Accession #
P31930
GenBank Nucleotide #
NM_003365.2
NCBI Official Full Name
cytochrome b-c1 complex subunit 1, mitochondrial
NCBI Official Synonym Full Names
ubiquinol-cytochrome c reductase core protein I
NCBI Official Symbol
UQCRC1
NCBI Official Synonym Symbols
QCR1; UQCR1; D3S3191
UniProt Protein Name
Cytochrome b-c1 complex subunit 1, mitochondrial
UniProt Synonym Protein Names
Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1
UniProt Gene Name
UQCRC1
UniProt Entry Name
QCR1_HUMAN
NCBI Protein Information
cytochrome b-c1 complex subunit 1, mitochondrial; core protein I; complex III subunit 1; ubiquinol-cytochrome-c reductase complex core protein 1

UniProt Comments for UQCRC1

UQCRC1: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.

Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; EC 1.10.2.2

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex III; mitochondrial respiratory chain

Molecular Function: metal ion binding; ubiquinol-cytochrome-c reductase activity; protein complex binding

Biological Process: response to alkaloid; cellular metabolic process; aerobic respiration; response to activity; mitochondrial electron transport, ubiquinol to cytochrome c; oxidative phosphorylation
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Research Articles on UQCRC1

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UQCRC1 antibody

 Reference Product  PubMed Publications
 UQCRC2 antibody  >4 publications with UQCRC1 and UQCRC2
 NDUFS3 antibody  >1 publications with UQCRC1 and NDUFS3
 COX5A antibody  >1 publications with UQCRC1 and COX5A
 NDUFV1 antibody  >1 publications with UQCRC1 and NDUFV1
 CYC1 antibody  >1 publications with UQCRC1 and CYC1
 UQCRQ antibody  >1 publications with UQCRC1 and UQCRQ

Pathways associated with anti-UQCRC1 antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cytochrome Bc1 Complex Pathway antibodies  Cytochrome Bc1 Complex Pathway Diagram
 Cytochrome Bc1 Complex Pathway antibodies  Cytochrome Bc1 Complex Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-UQCRC1 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >4 publications with UQCRC1 and Insulin Resistance
 Cardiovascular Diseases Antibodies  >2 publications with UQCRC1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >2 publications with UQCRC1 and Nervous System Diseases
 Weight Gain Antibodies  >1 publications with UQCRC1 and Weight Gain
 Vascular Diseases Antibodies  >1 publications with UQCRC1 and Vascular Diseases
 Hypertrophy Antibodies  >1 publications with UQCRC1 and Hypertrophy
 Diabetes Mellitus Antibodies  >1 publications with UQCRC1 and Diabetes Mellitus
 Heart Diseases Antibodies  >1 publications with UQCRC1 and Heart Diseases
 Inflammation Antibodies  >1 publications with UQCRC1 and Inflammation
 Cardiovascular Abnormalities Antibodies  >1 publications with UQCRC1 and Cardiovascular Abnormalities

Organs/Tissues associated with anti-UQCRC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with UQCRC1 and Muscle
 Brain Antibodies  >4 publications with UQCRC1 and Brain
 Vascular Antibodies  >2 publications with UQCRC1 and Vascular
 Heart Antibodies  >2 publications with UQCRC1 and Heart
 Liver Antibodies  >2 publications with UQCRC1 and Liver
 Ovary Antibodies  >2 publications with UQCRC1 and Ovary
 Bone Antibodies  >1 publications with UQCRC1 and Bone
 Blood Antibodies  >1 publications with UQCRC1 and Blood
 Uterus Antibodies  >1 publications with UQCRC1 and Uterus
 Nerve Antibodies  >1 publications with UQCRC1 and Nerve
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