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STK17B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249158

STK17B, a DAPK type protein kinase, functions in apoptotic signaling. In vitro assays have shown that protein is autophosphorylated. Messanger RNAs of various in sizes have been reported, likely due to differences of 3' untranslated region. More details

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Product Overview

Product Name
STK17B / DRAK2, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2C3] (IgG2b,k) to Human STK17B / DRAK2
Product Gene Name
anti-STK17B antibody
Product Synonym Gene Name
DRAK2
Product Synonym Names
Anti-STK17B / DRAK2 Antibody (clone 2C3) IHC-plus; STK17B; DRAK2; Serine/threonine kinase 17b; Human STK17B; DRAK2
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2C3
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2
Purity/Purification
Protein A Purified
Concentration
0.37 mg/ml (lot specific)
Specificity
Human DRAK2
Preparation and Storage
Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
42,344 Da
OMIM
604727
3D Structure
ModBase 3D Structure for O94768
Target Species
Human
Immunogen Description
STK17B (AAH16040, 272 a.a. ~ 372 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
STK17B / DRAK2 antibody was raised against sTK17B (AAH16040, 272 a.a. ~ 372 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Product Categories/Family for anti-STK17B antibody

Family: Protein Kinase; Subfamily: DAPK
Applications Tested/Suitable for anti-STK17B antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-STK17B antibody
ELISA, IF (10 ug/ml), IHC-P (3 - 5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-STK17B antibody

Anti-STK17B / DRAK2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Mouse Anti-STK17B Monoclonal Antibody – Cat# MBS249158

Immunofluorescence (IF) of anti-STK17B antibody

Immunofluorescence of monoclonal antibody to STK17B on HeLa cell. [antibody concentration 10 ug/ml]
Mouse Anti-STK17B Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS249158

Western Blot (WB) of anti-STK17B antibody

STK17B monoclonal antibody (M01), clone 2C3 Western blot of STK17B expression in Jurkat.
Mouse Anti-STK17B Monoclonal Antibody, Western Blot (WB) – Cat# MBS249158

ELISA (EIA) of anti-STK17B antibody

Detection limit for recombinant GST tagged STK17B is approximately 0.3 ng/ml as a capture antibody.
Mouse Anti-STK17B Monoclonal Antibody, ELISA (EIA) – Cat# MBS249158

Other Notes

Small volumes of anti-STK17B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STK17B purchase

MBS249158 is an antibody targeting STK17B. Also known as Mouse Monoclonal [clone 2C3] (IgG2b,k) to Human STK17B / DRAK2. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for STK17B. It may not necessarily be applicable to this product.

NCBI GI #
4758194
NCBI GeneID
9262
NCBI Accession #
NP_004217.1
UniProt Primary Accession #
O94768
UniProt Related Accession #
O94768
GenBank Nucleotide #
NM_004226.3
NCBI Official Full Name
serine/threonine-protein kinase 17B
NCBI Official Synonym Full Names
serine/threonine kinase 17b
NCBI Official Symbol
STK17B
NCBI Official Synonym Symbols
DRAK2
UniProt Protein Name
Serine/threonine-protein kinase 17B
UniProt Synonym Protein Names
DAP kinase-related apoptosis-inducing protein kinase 2
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
STK17B
UniProt Synonym Gene Names
DRAK2
UniProt Entry Name
ST17B_HUMAN
NCBI Protein Information
serine/threonine-protein kinase 17B; death-associated protein kinase-related 2; DAP kinase-related apoptosis-inducing protein kinase 2

UniProt Comments for STK17B

DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: ER-Golgi intermediate compartment; plasma membrane; nucleus; actin cytoskeleton

Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity

Biological Process: apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation
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Research Articles on STK17B

1. A significant interaction between variants in STK17B and PAX8, in papillary thyroid cancer susceptibility, is reported.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STK17B antibody

 Reference Product  PubMed Publications
 CHP antibody  >2 publications with STK17B and CHP
 SP140L antibody  >1 publications with STK17B and SP140L

Diseases associated with anti-STK17B antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with STK17B and Carcinoma
 Breast Neoplasms Antibodies  >2 publications with STK17B and Breast Neoplasms
 Adenocarcinoma Antibodies  >2 publications with STK17B and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with STK17B and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with STK17B and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with STK17B and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >1 publications with STK17B and Fibrosis
 Hyperplasia Antibodies  >1 publications with STK17B and Hyperplasia
 Infertility, Male Antibodies  >1 publications with STK17B and Infertility, Male
 Carcinoma, Hepatocellular Antibodies  >1 publications with STK17B and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-STK17B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with STK17B and Blood
 Brain Antibodies  >3 publications with STK17B and Brain
 Spleen Antibodies  >2 publications with STK17B and Spleen
 Bone Antibodies  >2 publications with STK17B and Bone
 Bone Marrow Antibodies  >1 publications with STK17B and Bone Marrow
 Thymus Antibodies  >1 publications with STK17B and Thymus
 Lung Antibodies  >1 publications with STK17B and Lung
 Intestine Antibodies  >1 publications with STK17B and Intestine
 Skin Antibodies  >1 publications with STK17B and Skin
 Kidney Antibodies  >1 publications with STK17B and Kidney
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