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GSC Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249166

MBS249166 is an antibody targeting GSC. Also known as Mouse Monoclonal [clone 2C1] (IgG2a,k) to Human GSC / Goosecoid. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GSC / Goosecoid, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2C1] (IgG2a,k) to Human GSC / Goosecoid
Product Gene Name
anti-GSC antibody
Product Synonym Names
Anti-GSC / Goosecoid Antibody (clone 2C1) IHC-plus; GSC; Goosecoid homeobox; Homeobox protein goosecoid; Goosecoid; Human GSC; Goosecoid
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2C1
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human GSC
Preparation and Storage
Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
28,150 Da
OMIM
gene 602471
3D Structure
ModBase 3D Structure for P56915
Target Species
Human
Immunogen Description
GSC (NP_776248, 78 a.a. ~ 186 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
GSC / Goosecoid antibody was raised against gSC (NP_776248, 78 a.a. ~ 186 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-GSC antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-GSC antibody
ELISA, IHC-P (3 - 10 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Western Blot: Tissue lysate, Recombinant protein.

Immunohistochemistry (IHC) of anti-GSC antibody

Anti-GSC / Goosecoid antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Mouse Anti-GSC Monoclonal Antibody – Cat# MBS249166

Western Blot (WB) of anti-GSC antibody

GSC monoclonal antibody (M17), clone 2C1. Western blot of GSC expression in human kidney.
Mouse Anti-GSC Monoclonal Antibody, Western Blot (WB) – Cat# MBS249166

Other Notes

Small volumes of anti-GSC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GSC. It may not necessarily be applicable to this product.

NCBI GI #
27777663
NCBI GeneID
145258
NCBI Accession #
NP_776248.1
UniProt Primary Accession #
P56915
UniProt Secondary Accession #
Q86YR1
UniProt Related Accession #
P56915
GenBank Nucleotide #
NM_173849.2
NCBI Official Full Name
homeobox protein goosecoid
NCBI Official Synonym Full Names
goosecoid homeobox
NCBI Official Symbol
GSC
NCBI Official Synonym Symbols
SAMS
UniProt Protein Name
Homeobox protein goosecoid
Protein Family
Homeobox protein
UniProt Gene Name
GSC
UniProt Entry Name
GSC_HUMAN
NCBI Protein Information
homeobox protein goosecoid

NCBI Summary for GSC

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for GSC

GSC: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: transcription factor complex; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: neural crest cell fate specification; negative regulation of Wnt receptor signaling pathway; forebrain development; gastrulation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; muscle morphogenesis; dorsoventral neural tube patterning; embryonic skeletal morphogenesis

Disease: Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities
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Research Articles on GSC

1. EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GSC antibody

 Reference Product  PubMed Publications
 SMAD2 antibody  >9 publications with GSC and SMAD2
 SMAD4 antibody  >6 publications with GSC and SMAD4
 EDN1 antibody  >5 publications with GSC and EDN1
 FOXH1 antibody  >5 publications with GSC and FOXH1
 E2F1 antibody  >2 publications with GSC and E2F1
 RB1 antibody  >1 publications with GSC and RB1

Pathways associated with anti-GSC antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram

Diseases associated with anti-GSC antibody

 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >28 publications with GSC and Craniofacial Abnormalities
 Abnormalities, Multiple Antibodies  >16 publications with GSC and Abnormalities, Multiple
 Disease Models, Animal Antibodies  >12 publications with GSC and Disease Models, Animal
 Necrosis Antibodies  >12 publications with GSC and Necrosis
 Neoplasm Metastasis Antibodies  >11 publications with GSC and Neoplasm Metastasis
 Liver Diseases Antibodies  >7 publications with GSC and Liver Diseases
 Eye Abnormalities Antibodies  >5 publications with GSC and Eye Abnormalities
 Cognition Disorders Antibodies  >5 publications with GSC and Cognition Disorders
 Jaw Abnormalities Antibodies  >5 publications with GSC and Jaw Abnormalities
 Abnormalities, Drug-Induced Antibodies  >5 publications with GSC and Abnormalities, Drug-Induced

Organs/Tissues associated with anti-GSC antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >102 publications with GSC and Embryonic Tissue
 Bone Antibodies  >86 publications with GSC and Bone
 Connective Tissue Antibodies  >8 publications with GSC and Connective Tissue
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