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TDO2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249361

TDO2 Antibody, TDO Antibody, TO Antibody, TRPO Antibody, Tryptophan pyrrolase Antibody, Tryptophan oxygenase Antibody, Tryptophan 2,3-dioxygenase Antibody, Tryptophanase Antibody, Tryptamin 2,3-dioxygenase Antibody Description: TDO2 is a heme enzyme that… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TDO2, Monoclonal Antibody
Full Product Name
Anti-TDO2 Antibody (clone 4G2) IHC-plus
Product Gene Name
Product Synonym Names
Mouse Monoclonal [clone 4G2] (IgG2a) to Human TDO2; Human TDO2; TDO; TO; TRPO; Tryptophan pyrrolase; Tryptophan oxygenase; Tryptophan 2,3-dioxygenase; Tryptophanase; Tryptamin 2,3-dioxygenase
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
4G2
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Purity/Purification
Protein A/G purified
Concentration
1 mg/ml (lot specific)
Specificity
Human TDO / TDO2
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
47,872 Da
OMIM
191070
3D Structure
ModBase 3D Structure for P48775
Immunogen
TDO2 antibody was raised against full length human recombinant protein of human TDO2(NP_005642) produced in HEK293T cell.
Immunogen Description
Full length human recombinant protein of human TDO2(NP_005642) produced in HEK293T cell.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-TDO2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-TDO2 antibody
IHC-P (10 ug/ml)
WB (1:2000)

Immunohistochemistry (IHC) of anti-TDO2 antibody

Anti-TDO / TPH2 / TDO2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Mouse Anti-TDO2 Monoclonal Antibody – Cat# MBS249361

Immunohistochemistry (IHC) of anti-TDO2 antibody

Anti-TDO / TPH2 / TDO2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-TDO2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS249361

Western Blot (WB) of anti-TDO2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.
Mouse Anti-TDO2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249361

Other Notes

Small volumes of anti-TDO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TDO2 purchase

MBS249361 is an antibody targeting TDO2. Also known as Anti-TDO2 Antibody (clone 4G2) IHC-plus. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TDO2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tryptophan 2,3-dioxygenase
NCBI Official Synonym Full Names
tryptophan 2,3-dioxygenase
NCBI Official Symbol
TDO2
NCBI Official Synonym Symbols
TO; TDO; TPH2; TRPO
UniProt Protein Name
Tryptophan 2,3-dioxygenase
UniProt Synonym Protein Names
Tryptamin 2,3-dioxygenase
UniProt Gene Name
TDO2
UniProt Synonym Gene Names
TDO; TO; TRPO
UniProt Entry Name
T23O_HUMAN
NCBI Protein Information
tryptophan 2,3-dioxygenase

NCBI Summary for TDO2

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
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UniProt Comments for TDO2

TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.

Protein type: EC 1.13.11.11; Oxidoreductase; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytosol

Molecular Function: amino acid binding; heme binding; metal ion binding; oxygen binding; protein binding; tryptophan 2,3-dioxygenase activity

Biological Process: tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TDO2 antibody

 Reference Product  PubMed Publications
 IDO2 antibody  >5 publications with TDO2 and IDO2
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