• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TPX2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249413

TPX2 Antibody, C20orf2 Antibody, DIL-2 Antibody, DIL2 Antibody, HCA519 Antibody, GD:C20orf1 Antibody, p100 Antibody, Protein fls353 Antibody, Targeting protein for Xklp2 Antibody, C20orf1 Antibody, FLS353 Antibody, HCTP4 Antibody, REPP86 Antibody Description:… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
TPX2, Monoclonal Antibody
Full Product Name
Anti-TPX2 Antibody (clone 19AT738.292) IHC-plus
Product Gene Name
Product Synonym Names
Mouse Monoclonal [clone 19AT738.292] (IgG1) to Human TPX2; Human TPX2; C20orf2; DIL-2; DIL2; HCA519; GD:C20orf1; p100; Protein fls353; Targeting protein for Xklp2; C20orf1; FLS353; HCTP4; REPP86
Clonality
Monoclonal
Isotype
IgG1
Clone Number
19AT738.292
Host
Mouse
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Protein G purified
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Molecular Weight
89,393 Da
OMIM
605917
3D Structure
ModBase 3D Structure for Q9ULW0
Immunogen
TPX2 antibody was raised against four KLH conjugated synthetic peptides selected from human P100.
Immunogen Description
Four KLH conjugated synthetic peptides selected from human P100.
Immunogen Type
Synthetic peptide
Target Species
Human
Applications Tested/Suitable for anti-TPX2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-TPX2 antibody
IHC-P (1:50)
WB (1:100 - 1:500)

Immunohistochemistry (IHC) of anti-TPX2 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mouse Anti-TPX2 Monoclonal Antibody – Cat# MBS249413

Western Blot (WB) of anti-TPX2 antibody

Western of extracts from Jurkat cells using P100 antibody.
Mouse Anti-TPX2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249413

Other Notes

Small volumes of anti-TPX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPX2 purchase

MBS249413 is an antibody targeting TPX2. Also known as Anti-TPX2 Antibody (clone 19AT738.292) IHC-plus. Reactive in Mouse, Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TPX2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
targeting protein for Xklp2
NCBI Official Synonym Full Names
TPX2, microtubule-associated
NCBI Official Symbol
TPX2
NCBI Official Synonym Symbols
DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
UniProt Protein Name
Targeting protein for Xklp2
UniProt Synonym Protein Names
Differentially expressed in cancerous and non-cancerous lung cells 2; DIL-2; Hepatocellular carcinoma-associated antigen 519; Hepatocellular carcinoma-associated antigen 90; Protein fls353; Restricted expression proliferation-associated protein 100; p100
Protein Family
UniProt Gene Name
TPX2
UniProt Synonym Gene Names
C20orf1; C20orf2; DIL2; HCA519; DIL-2; p100
UniProt Entry Name
TPX2_HUMAN
NCBI Protein Information
targeting protein for Xklp2

UniProt Comments for TPX2

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000