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ALPHA SNAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249501

NAPA Antibody, Alpha SNAP Antibody, Alpha-SNAP Antibody, SNAP-alpha Antibody, SNAPA Antibody Description: The 'sNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane… More details

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Product Overview

Product Name
Alpha SNAP, Polyclonal Antibody
Full Product Name
Anti-Alpha SNAP Antibody (aa78-295) IHC-plus
Product Gene Name
anti-Alpha SNAP antibody
Product Synonym Gene Name
NAPA
Product Synonym Names
Rabbit Polyclonal (IgG) to Human Alpha SNAP; Human Alpha SNAP; Alpha-SNAP; SNAP-alpha; SNAPA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat, Human, Monkey
Form/Format
0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
Human Alpha SNAP
Preparation and Storage
Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.
Molecular Weight
33,233 Da
OMIM
603215
3D Structure
ModBase 3D Structure for P54920
Immunogen
Alpha SNAP antibody was raised against recombinant fragment corresponding to a region within amino acids 78 and 295 of alpha SNAP (SwissProt P54920). Percent identity by BLAST analysis: Human, Monkey (100%); Bovine (98%); Rat (97%); Xenopus (89%); Zebrafish (85%).
Immunogen Description
Recombinant fragment corresponding to a region within amino acids 78 and 295 of alpha SNAP (SwissProt P54920). Percent identity by BLAST analysis: Human, Monkey (100%); Bovine (98%); Rat (97%); Xenopus (89%); Zebrafish (85%).
Immunogen Type
Recombinant protein
Antigen Modification
aa78-295
Target Species
Human
Applications Tested/Suitable for anti-Alpha SNAP antibody
Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-Alpha SNAP antibody
ICC (1:100 - 1:1000)
IHC-P (7.5 ug/ml)
WB (1:1000 - 1:10000)

Immunohistochemistry (IHC) of anti-Alpha SNAP antibody

Anti-Alpha SNAP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.
Rabbit Anti-ALPHA SNAP Polyclonal Antibody – Cat# MBS249501

Immunocytochemistry (ICC) of anti-Alpha SNAP antibody

Immunofluorescence of methanol-fixed A431 using alpha SNAP antibody at 1:200 dilution.
Rabbit Anti-ALPHA SNAP Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS249501

Western Blot (WB) of anti-Alpha SNAP antibody

Sample (30 ug whole cell lysate). A: Hep G2. 10% SDS PAGE. Alpha SNAP antibody diluted at 1:1000
Rabbit Anti-ALPHA SNAP Polyclonal Antibody, Western Blot (WB) – Cat# MBS249501

Western Blot (WB) of anti-Alpha SNAP antibody

Sample (50 ug of whole cell lysate). A: mouse brain. 12% SDS PAGE. Alpha SNAP antibody diluted at 1:10000.
Rabbit Anti-ALPHA SNAP Polyclonal Antibody, Western Blot (WB) – Cat# MBS249501

Other Notes

Small volumes of anti-Alpha SNAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Alpha SNAP purchase

MBS249501 is an antibody targeting Alpha SNAP. Also known as Anti-Alpha SNAP Antibody (aa78-295) IHC-plus. Reactive in Mouse, Rat, Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Alpha SNAP. It may not necessarily be applicable to this product.

NCBI GI #
47933379
NCBI GeneID
8775
NCBI Accession #
NP_003818.2
UniProt Primary Accession #
P54920
UniProt Secondary Accession #
Q96IK3; Q9BVJ3; A8K879
UniProt Related Accession #
P54920
GenBank Nucleotide #
NM_003827.3
NCBI Official Full Name
alpha-soluble NSF attachment protein
NCBI Official Synonym Full Names
NSF attachment protein alpha
NCBI Official Symbol
NAPA
NCBI Official Synonym Symbols
SNAPA
UniProt Protein Name
Alpha-soluble NSF attachment protein
UniProt Synonym Protein Names
N-ethylmaleimide-sensitive factor attachment protein alpha
Protein Family
Alpha-soluble NSF attachment protein
UniProt Gene Name
NAPA
UniProt Synonym Gene Names
SNAPA; SNAP-alpha
UniProt Entry Name
SNAA_HUMAN
NCBI Protein Information
alpha-soluble NSF attachment protein

NCBI Summary for Alpha SNAP

This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
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UniProt Comments for Alpha SNAP

SNAP-alpha: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Belongs to the SNAP family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytosol; Golgi membrane; membrane; myelin sheath; SNARE complex; terminal button; vacuolar membrane

Molecular Function: protein binding; soluble NSF attachment protein activity; syntaxin binding

Biological Process: apical protein localization; brain development; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; neuron differentiation; post-Golgi vesicle-mediated transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; synaptic transmission, glutamatergic
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Research Articles on Alpha SNAP

1. data implicates beta1 integrin, FAK, and paxillin in mediating the observed pro-adhesive effects of alphaSNAP. These results reveal novel roles for alphaSNAP in regulating ECM adhesion and motility of epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Alpha SNAP antibody

 Reference Product  PubMed Publications
 NSF antibody  >4 publications with Alpha SNAP and NSF
 STX8 antibody  >1 publications with Alpha SNAP and STX8
 VAMP7 antibody  >1 publications with Alpha SNAP and VAMP7
 VAMP2 antibody  >1 publications with Alpha SNAP and VAMP2
 STX7 antibody  >1 publications with Alpha SNAP and STX7

Pathways associated with anti-Alpha SNAP antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram

Diseases associated with anti-Alpha SNAP antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >64 publications with Alpha SNAP and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >52 publications with Alpha SNAP and Nervous System Diseases
 Poisoning Antibodies  >21 publications with Alpha SNAP and Poisoning
 Kidney Diseases Antibodies  >21 publications with Alpha SNAP and Kidney Diseases
 Immune System Diseases Antibodies  >15 publications with Alpha SNAP and Immune System Diseases
 Inflammation Antibodies  >15 publications with Alpha SNAP and Inflammation
 Neurobehavioral Manifestations Antibodies  >10 publications with Alpha SNAP and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >9 publications with Alpha SNAP and Disease Models, Animal
 Liver Diseases Antibodies  >8 publications with Alpha SNAP and Liver Diseases
 Cognition Disorders Antibodies  >7 publications with Alpha SNAP and Cognition Disorders

Organs/Tissues associated with anti-Alpha SNAP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >144 publications with Alpha SNAP and Blood
 Heart Antibodies  >64 publications with Alpha SNAP and Heart
 Kidney Antibodies  >44 publications with Alpha SNAP and Kidney
 Brain Antibodies  >36 publications with Alpha SNAP and Brain
 Liver Antibodies  >27 publications with Alpha SNAP and Liver
 Muscle Antibodies  >21 publications with Alpha SNAP and Muscle
 Skin Antibodies  >11 publications with Alpha SNAP and Skin
 Lung Antibodies  >10 publications with Alpha SNAP and Lung
 Stomach Antibodies  >10 publications with Alpha SNAP and Stomach
 Bone Antibodies  >9 publications with Alpha SNAP and Bone
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