Rabbit Anti-GC Polyclonal Antibody – Cat# MBS249518

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

GC Antibody – Rabbit Polyclonal

Name: GC Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS249518
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249518

GC Antibody, Gc-globulin Antibody, HDBP Antibody, Group-specific component Antibody, GRD3 Antibody, VDB Antibody, VDBG Antibody, VDBP Antibody, Vitamin D-binding protein Antibody Description: Multifunctional protein found in plasma, ascitic fluid,… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GC / Vitamin D-Binding Protein, Polyclonal Antibody

Full Product Name

Anti-GC / Vitamin D-Binding Protein Antibody IHC-plus

Product Gene Name

anti-GC antibody

Product Synonym Names

Rabbit Polyclonal (IgG) to Human GC / Vitamin D-Binding Protein; Human GC / Vitamin D-Binding Protein; Gc-globulin; HDBP; Group-specific component; GRD3; VDB; VDBG; VDBP; Vitamin D-binding protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.

Purity/Purification

Caprylic acid and ammonium sulfate precipitation

Specificity

Human GC / Vitamin D-Binding Protein

Preparation and Storage

Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles

Molecular Weight

55,123 Da

OMIM

139200

3D Structure

ModBase 3D Structure for P02774

Immunogen

GC / Vitamin D-Binding Protein antibody was raised against recombinant human Vitamin D-binding protein.

Immunogen Description

Recombinant human Vitamin D-binding protein.

Immunogen Type

Recombinant protein

Target Species

Human

Applications Tested/Suitable for anti-GC antibody

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)

Application Notes for anti-GC antibody

IHC-P (10 ug/ml)

Other Notes

Small volumes of anti-GC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GC purchase

MBS249518 is an antibody targeting GC. Also known as Anti-GC / Vitamin D-Binding Protein Antibody IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GC. It may not necessarily be applicable to this product.

NCBI GI #

32483410

NCBI GeneID

2638

NCBI Accession #

NP_000574.2

UniProt Primary Accession #

P02774

UniProt Secondary Accession #

Q16309; Q16310; Q53F31; Q6GTG1; B4DPP2; D6RAK8

UniProt Related Accession #

P02774

GenBank Nucleotide #

NM_000583.3

NCBI Official Full Name

vitamin D-binding protein isoform 1

NCBI Official Synonym Full Names

group-specific component (vitamin D binding protein)

NCBI Official Symbol

NCBI Official Synonym Symbols

DBP; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; HEL-S-51

UniProt Protein Name

Vitamin D-binding protein

UniProt Synonym Protein Names

Gc protein-derived macrophage activating factor

Protein Family

Envelope glycoprotein

UniProt Gene Name

UniProt Synonym Gene Names

DBP-maf

UniProt Entry Name

VTDB_HUMAN

NCBI Protein Information

vitamin D-binding protein

NCBI Summary for GC

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

UniProt Comments for GC

GC: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q12-q13

Cellular Component: axon; cytosol; extracellular region; extracellular space; lysosomal lumen; perinuclear region of cytoplasm

Molecular Function: actin binding; vitamin D binding; vitamin transporter activity

Biological Process: fat-soluble vitamin metabolic process; female pregnancy; lactation; response to estradiol stimulus; response to nutrient levels; vitamin D metabolic process; vitamin metabolic process; vitamin transport

Disease: Graves Disease, Susceptibility To, 1

Research Articles on GC

1. Low serum 25(OH)D was independently associated with incident HF among whites, but not among blacks. However, in both races, low 25(OH)D was associated with HF risk among those genetically predisposed to high DBP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GC antibody

Reference Product	PubMed Publications
GSR antibody	>11 publications with GC and GSR
ACTA2 antibody	>3 publications with GC and ACTA2
SELENBP1 antibody	>3 publications with GC and SELENBP1
CUBN antibody	>2 publications with GC and CUBN
LRP2 antibody	>2 publications with GC and LRP2
SLC25A18 antibody	>1 publications with GC and SLC25A18
ACTA1 antibody	>1 publications with GC and ACTA1

Pathways associated with anti-GC antibody

Products by Pathway	Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Fat-soluble Vitamins Pathway antibodies	Metabolism Of Fat-soluble Vitamins Pathway Diagram
Metabolism Of Vitamins And Cofactors Pathway antibodies	Metabolism Of Vitamins And Cofactors Pathway Diagram
Vitamin D (calciferol) Metabolism Pathway antibodies	Vitamin D (calciferol) Metabolism Pathway Diagram
Vitamin D Synthesis Pathway antibodies	Vitamin D Synthesis Pathway Diagram

Diseases associated with anti-GC antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>1969 publications with GC and Immune System Diseases
Inflammation Antibodies	>1286 publications with GC and Inflammation
Cardiovascular Diseases Antibodies	>1108 publications with GC and Cardiovascular Diseases
Lung Diseases Antibodies	>846 publications with GC and Lung Diseases
Poisoning Antibodies	>782 publications with GC and Poisoning
Liver Diseases Antibodies	>772 publications with GC and Liver Diseases
Necrosis Antibodies	>765 publications with GC and Necrosis
Kidney Diseases Antibodies	>462 publications with GC and Kidney Diseases
Breast Neoplasms Antibodies	>421 publications with GC and Breast Neoplasms
Hypertension Antibodies	>421 publications with GC and Hypertension

Organs/Tissues associated with anti-GC antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>10646 publications with GC and Blood
Liver Antibodies	>3234 publications with GC and Liver
Muscle Antibodies	>1591 publications with GC and Muscle
Kidney Antibodies	>1429 publications with GC and Kidney
Lung Antibodies	>1407 publications with GC and Lung
Heart Antibodies	>1140 publications with GC and Heart
Intestine Antibodies	>804 publications with GC and Intestine
Ovary Antibodies	>774 publications with GC and Ovary
Connective Tissue Antibodies	>630 publications with GC and Connective Tissue
Spleen Antibodies	>568 publications with GC and Spleen