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ADCY1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249587

ADCY1 Antibody, 3,5-cyclic AMP synthetase Antibody, Adenylate cyclase type I Antibody, AC1 Antibody, Adenylate cyclase type 1 Antibody, Adenylyl cyclase 1 Antibody, ATP pyrophosphate-lyase 1 Antibody, Adenyl cyclase Antibody, Adenylate cyclase 1 (brain)… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
ADCY1 / Adenylate Cyclase 1, Polyclonal Antibody
Full Product Name
Anti-ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) IHC-plus
Product Gene Name
anti-ADCY1 antibody
Product Synonym Names
Rabbit Polyclonal (IgG) to Human ADCY1 / Adenylate Cyclase 1; Human ADCY1 / Adenylate Cyclase 1; 3,5-cyclic AMP synthetase; Adenylate cyclase type I; AC1; Adenylate cyclase type 1; Adenylyl cyclase 1; ATP pyrophosphate-lyase 1; Adenyl cyclase; Adenylate cyclase 1 (brain); Adenylate cyclase; type i; ATP pyrophosphate-lyase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
ADCY1 Antibody detects endogenous levels of total ADCY1 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
123,440 Da
OMIM
103072
3D Structure
ModBase 3D Structure for Q08828
Immunogen
ADCY1 / Adenylate Cyclase 1 antibody was raised against synthetic peptide from human ADCY1 (aa231-280).
Immunogen Description
Synthetic peptide from human ADCY1 (aa231-280).
Antigen Modification
aa231-280
Target Species
Human
Applications Tested/Suitable for anti-ADCY1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-ADCY1 antibody
ELISA (1:40000)
IHC-P (10 ug/ml)
WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-ADCY1 antibody

Huma Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-ADCY1 Polyclonal Antibody – Cat# MBS249587

Immunohistochemistry (IHC) of anti-ADCY1 antibody

Anti-ADCY1 / Adenylate Cyclase 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ADCY1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS249587

Western Blot (WB) of anti-ADCY1 antibody

Western blot of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-ADCY1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249587

Other Notes

Small volumes of anti-ADCY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADCY1 purchase

MBS249587 is an antibody targeting ADCY1. Also known as Anti-ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCY1. It may not necessarily be applicable to this product.

NCBI GI #
62512172
NCBI GeneID
107
NCBI Accession #
Q08828.2
UniProt Primary Accession #
Q08828
UniProt Secondary Accession #
Q75MI1; A4D2L8
UniProt Related Accession #
Q08828
NCBI Official Full Name
Adenylate cyclase type 1
NCBI Official Synonym Full Names
adenylate cyclase 1 (brain)
NCBI Official Symbol
ADCY1
NCBI Official Synonym Symbols
AC1; DFNB44
UniProt Protein Name
Adenylate cyclase type 1
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY1
UniProt Entry Name
ADCY1_HUMAN
NCBI Protein Information
adenylate cyclase type 1

NCBI Summary for ADCY1

This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for ADCY1

ADCY1: a calmodulin-sensitive adenylyl cyclase expressed in brain. The mouse protein is involved in pattern formation of the brain. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.

Protein type: Transporter, aquaporin family; Lyase; Nucleotide Metabolism - purine; Transporter; Membrane protein, multi-pass; Adenylyl cyclase; Membrane protein, integral; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: cytoplasm; integral to plasma membrane; lipid raft; nucleus; plasma membrane

Molecular Function: adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding

Biological Process: activation of protein kinase A; axonogenesis; cAMP biosynthetic process; cAMP-mediated signaling; circadian rhythm; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; innate immune response; long-term memory; nerve growth factor receptor signaling pathway; phospholipase C activation; regulation of circadian rhythm; renal water homeostasis; response to drug; response to lithium ion; signal transduction; synaptic transmission; transmembrane transport; water transport

Disease: Deafness, Autosomal Recessive 44
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Research Articles on ADCY1

1. STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADCY1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram

Diseases associated with anti-ADCY1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with ADCY1 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with ADCY1 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with ADCY1 and Cell Transformation, Neoplastic
 Depressive Disorder Antibodies  >1 publications with ADCY1 and Depressive Disorder
 Hyperglycemia Antibodies  >1 publications with ADCY1 and Hyperglycemia
 Abnormalities, Drug-Induced Antibodies  >1 publications with ADCY1 and Abnormalities, Drug-Induced
 Glucose Intolerance Antibodies  >1 publications with ADCY1 and Glucose Intolerance

Organs/Tissues associated with anti-ADCY1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with ADCY1 and Brain
 Eye Antibodies  >8 publications with ADCY1 and Eye
 Nerve Antibodies  >4 publications with ADCY1 and Nerve
 Embryonic Tissue Antibodies  >3 publications with ADCY1 and Embryonic Tissue
 Pancreas Antibodies  >2 publications with ADCY1 and Pancreas
 Kidney Antibodies  >2 publications with ADCY1 and Kidney
 Bone Antibodies  >1 publications with ADCY1 and Bone
 Skin Antibodies  >1 publications with ADCY1 and Skin
 Heart Antibodies  >1 publications with ADCY1 and Heart
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