MRGPRX2 / MRGX2 Antibody – Rabbit Polyclonal

MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: integral to membrane; integral to plasma membrane; mast cell granule

Molecular Function: G-protein coupled receptor activity; neuropeptide binding

Biological Process: G-protein coupled receptor protein signaling pathway; mast cell activation; mast cell degranulation; positive regulation of cytokinesis; sensory perception of pain; sleep