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LZTS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249719

LZTS2 Antibody, HLZTS2 Antibody, KIAA1813 Antibody, LAPSER1 Antibody, RP11-108L7.8 Antibody, Protein LAPSER1 Antibody Description: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LZTS2, Polyclonal Antibody
Full Product Name
Anti-LZTS2 Antibody (N-Terminus) IHC-plus
Product Gene Name
anti-LZTS2 antibody
Product Synonym Names
Rabbit Polyclonal to Human LZTS2; Human LZTS2; HLZTS2; KIAA1813; LAPSER1; RP11-108L7.8; Protein LAPSER1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
Human LZTS2. LZTS2 antibody is predicted to not cross-react with other LZTS family members.
Preparation and Storage
Short term 4 degree C
Long term aliquot and store at -20 degree C
Avoid freeze thaw cycles. Store undiluted.
Molecular Weight
72,759 Da
OMIM
610454
3D Structure
ModBase 3D Structure for Q9BRK4
Immunogen
LZTS2 antibody was raised against a 19 amino acid peptide near the amino terminus of human LZTS2
Immunogen Description
A 19 amino acid peptide near the amino terminus of human LZTS2
Immunogen Type
Synthetic peptide
Antigen Modification
N-Terminus
Target Species
Human
Applications Tested/Suitable for anti-LZTS2 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-LZTS2 antibody
IF (20 ug/ml)
IHC-P (5 ug/ml)
WB (1 ug/ml)

Immunohistochemistry (IHC) of anti-LZTS2 antibody

Anti-LZTS2 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-LZTS2 Polyclonal Antibody – Cat# MBS249719

Immunofluorescence (IF) of anti-LZTS2 antibody

Immunofluorescence of LZTS2 in human kidney tissue with LZTS2 antibody at 20 µg/mL.
Rabbit Anti-LZTS2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS249719

Western Blot (WB) of anti-LZTS2 antibody

Western blot analysis of LZTS2 in human kidney tissue lysate with LZTS2 antibody at 1 ug/ml.
Rabbit Anti-LZTS2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS249719

Other Notes

Small volumes of anti-LZTS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LZTS2 purchase

MBS249719 is an antibody targeting LZTS2. Also known as Anti-LZTS2 Antibody (N-Terminus) IHC-plus. Reactive in Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LZTS2. It may not necessarily be applicable to this product.

NCBI GI #
45331215
NCBI GeneID
84445
NCBI Accession #
NP_115805.1
UniProt Primary Accession #
Q9BRK4
UniProt Secondary Accession #
Q8N3I0; Q96J79; Q96JL2; B1AL14; D3DR72
UniProt Related Accession #
Q9BRK4
GenBank Nucleotide #
NM_032429.3
NCBI Official Full Name
leucine zipper putative tumor suppressor 2 isoform a
NCBI Official Synonym Full Names
leucine zipper, putative tumor suppressor 2
NCBI Official Symbol
LZTS2
NCBI Official Synonym Symbols
LAPSER1
UniProt Protein Name
Leucine zipper putative tumor suppressor 2
UniProt Synonym Protein Names
Protein LAPSER1
Protein Family
Leucine zipper putative tumor suppressor
UniProt Gene Name
LZTS2
UniProt Synonym Gene Names
hLZTS2
UniProt Entry Name
LZTS2_HUMAN
NCBI Protein Information
leucine zipper putative tumor suppressor 2

NCBI Summary for LZTS2

The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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UniProt Comments for LZTS2

LZTS2: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.

Protein type: Nuclear export

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: centrosome; cytoplasm; microtubule; midbody

Molecular Function: protein binding

Biological Process: cytokinesis; kidney development; microtubule severing; mitosis; negative regulation of cell proliferation; nuclear export; spindle midzone assembly; Wnt receptor signaling pathway
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Research Articles on LZTS2

1. LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt pathway, including GSK3B and beta-catenin through inactivating the Akt pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LZTS2 antibody

 Reference Product  PubMed Publications
 SIPA1L2 antibody  >1 publications with LZTS2 and SIPA1L2

Diseases associated with anti-LZTS2 antibody

 Disease Name  Pubmed Publications
 Kidney Neoplasms Antibodies  >2 publications with LZTS2 and Kidney Neoplasms
 Liver Neoplasms Antibodies  >2 publications with LZTS2 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with LZTS2 and Neoplasms, Experimental

Organs/Tissues associated with anti-LZTS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >4 publications with LZTS2 and Prostate
 Liver Antibodies  >3 publications with LZTS2 and Liver
 Kidney Antibodies  >3 publications with LZTS2 and Kidney
 Brain Antibodies  >3 publications with LZTS2 and Brain
 Lung Antibodies  >2 publications with LZTS2 and Lung
 Testis Antibodies  >1 publications with LZTS2 and Testis
 Adipose Tissue Antibodies  >1 publications with LZTS2 and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with LZTS2 and Connective Tissue
 Heart Antibodies  >1 publications with LZTS2 and Heart
 Embryonic Tissue Antibodies  >1 publications with LZTS2 and Embryonic Tissue
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