APOD Antibody – Rabbit Polyclonal

This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]

APOD: APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cell soma; dendrite; endoplasmic reticulum; extracellular region; extracellular space; perinuclear region of cytoplasm

Molecular Function: cholesterol binding; lipid transporter activity; protein binding

Biological Process: aging; angiogenesis; axon regeneration in the peripheral nervous system; brain development; glucose metabolic process; lipid metabolic process; lipid transport; negative regulation of focal adhesion formation; negative regulation of protein import into nucleus; negative regulation of smooth muscle cell proliferation; response to axon injury; response to drug; response to reactive oxygen species; tissue regeneration