ADCY9 Antibody – Rabbit Polyclonal

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

ADCY9: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Membrane protein, multi-pass; Nucleotide Metabolism - purine; Membrane protein, integral; Transporter; Transporter, aquaporin family; Lyase; EC 4.6.1.1; Adenylyl cyclase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: axon; dendrite; integral to membrane; integral to plasma membrane; intracellular; plasma membrane

Molecular Function: adenylate cyclase activity; ATP binding; metal ion binding

Biological Process: activation of protein kinase A; cAMP biosynthetic process; cAMP-mediated signaling; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; innate immune response; nerve growth factor receptor signaling pathway; phospholipase C activation; renal water homeostasis; signal transduction; synaptic transmission; transmembrane transport; water transport