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SPON2 / MINDIN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249947

SPON2 Antibody, DIL-1 Antibody, DIL1 Antibody, M-SPONDIN Antibody, Spondin-2 Antibody, MINDIN Antibody Description: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SPON2 / MINDIN, Polyclonal Antibody
Full Product Name
Anti-SPON2 / MINDIN Antibody (aa55-104) IHC-plus
Product Gene Name
anti-SPON2 / MINDIN antibody
Product Synonym Names
Rabbit Polyclonal (IgG) to Human SPON2 / MINDIN; Human SPON2 / MINDIN; DIL-1; DIL1; M-SPONDIN; Spondin-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat, Human
Form/Format
PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity purified
Concentration
1 mg/ml (lot specific)
Specificity
SPON2 Antibodyantibody detects endogenous levels of SPON2.
Preparation and Storage
Store at -20 degree C.
Molecular Weight
35,846 Da
OMIM
605918
3D Structure
ModBase 3D Structure for Q9BUD6
Immunogen
SPON2 / MINDIN antibody was raised against synthetic peptide from human SPON2 (aa55-104).
Immunogen Description
Synthetic peptide from human SPON2 (aa55-104).
Antigen Modification
aa55-104
Target Species
Human
Applications Tested/Suitable for anti-SPON2 / MINDIN antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-SPON2 / MINDIN antibody
ELISA (1:10000)
IHC-P (5 ug/ml)
WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-SPON2 / MINDIN antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-SPON2 / MINDIN Polyclonal Antibody – Cat# MBS249947

Immunohistochemistry (IHC) of anti-SPON2 / MINDIN antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-SPON2 / MINDIN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS249947

Western Blot (WB) of anti-SPON2 / MINDIN antibody

Western blot of the lysates from HUVEC cells using SPON2 antibody.
Rabbit Anti-SPON2 / MINDIN Polyclonal Antibody, Western Blot (WB) – Cat# MBS249947

Other Notes

Small volumes of anti-SPON2 / MINDIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPON2 / MINDIN purchase

MBS249947 is an antibody targeting SPON2 / MINDIN. Also known as Anti-SPON2 / MINDIN Antibody (aa55-104) IHC-plus. Reactive in Mouse, Rat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPON2 / MINDIN. It may not necessarily be applicable to this product.

NCBI GI #
6912682
NCBI GeneID
10417
NCBI Accession #
NP_036577.1
UniProt Primary Accession #
Q9BUD6
UniProt Secondary Accession #
Q4W5N4; Q9ULW1; D3DVN9
UniProt Related Accession #
Q9BUD6
GenBank Nucleotide #
NM_012445.3
NCBI Official Full Name
spondin-2
NCBI Official Synonym Full Names
spondin 2
NCBI Official Symbol
SPON2
NCBI Official Synonym Symbols
DIL1; DIL-1; MINDIN; M-SPONDIN
UniProt Protein Name
Spondin-2
UniProt Synonym Protein Names
Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin
UniProt Gene Name
SPON2
UniProt Synonym Gene Names
DIL1; DIL-1
UniProt Entry Name
SPON2_HUMAN
NCBI Protein Information
spondin-2

UniProt Comments for SPON2 / MINDIN

SPON2: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens. Binds bacterial lipopolysaccharide (LPS).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: extracellular space; proteinaceous extracellular matrix

Molecular Function: antigen binding; lipopolysaccharide binding; metal ion binding; protein binding

Biological Process: axon guidance; cell adhesion; defense response to fungus; defense response to virus; induction of bacterial agglutination; innate immune response; mast cell mediated immunity; opsonization; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production
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Research Articles on SPON2 / MINDIN

1. Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT-dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SPON2 / MINDIN antibody

 Reference Product  PubMed Publications
 MTUS1 antibody  >1 publications with SPON2 / MINDIN and MTUS1
 TPX2 antibody  >1 publications with SPON2 / MINDIN and TPX2

Pathways associated with anti-SPON2 / MINDIN antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram

Diseases associated with anti-SPON2 / MINDIN antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >7 publications with SPON2 / MINDIN and Prostatic Neoplasms
 Necrosis Antibodies  >2 publications with SPON2 / MINDIN and Necrosis
 Neoplasms, Experimental Antibodies  >1 publications with SPON2 / MINDIN and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with SPON2 / MINDIN and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with SPON2 / MINDIN and Liver Diseases
 Lung Neoplasms Antibodies  >1 publications with SPON2 / MINDIN and Lung Neoplasms
 Liver Neoplasms Antibodies  >1 publications with SPON2 / MINDIN and Liver Neoplasms
 Fibrosis Antibodies  >1 publications with SPON2 / MINDIN and Fibrosis
 Kidney Diseases Antibodies  >1 publications with SPON2 / MINDIN and Kidney Diseases
 Inflammation Antibodies  >1 publications with SPON2 / MINDIN and Inflammation

Organs/Tissues associated with anti-SPON2 / MINDIN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with SPON2 / MINDIN and Blood
 Liver Antibodies  >2 publications with SPON2 / MINDIN and Liver
 Lung Antibodies  >1 publications with SPON2 / MINDIN and Lung
 Brain Antibodies  >1 publications with SPON2 / MINDIN and Brain
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