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TRIP / LRRFIP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249951

LRRFIP1 Antibody, FLAP-1 Antibody, FLAP1 Antibody, FLIIAP1 Antibody, GCF2 Antibody, LRR FLII-interacting protein 1 Antibody, HUFI-1 Antibody, Tcf9 Antibody, Tcf-9 Antibody, TRIP Antibody, NEDD8-conjugating enzyme Antibody, TAR RNA-interacting protein… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TRIP / LRRFIP1, Polyclonal Antibody
Full Product Name
Anti-TRIP / LRRFIP1 Antibody IHC-plus
Product Gene Name
anti-TRIP / LRRFIP1 antibody
Product Synonym Names
Rabbit Polyclonal (IgG) to Human TRIP / LRRFIP1; Human TRIP / LRRFIP1; LRRFIP1; FLAP-1; FLAP1; FLIIAP1; GCF2; LRR FLII-interacting protein 1; HUFI-1; Tcf9; Tcf-9; TRIP; NEDD8-conjugating enzyme; TAR RNA-interacting protein; Transcription factor 9; GC-binding factor 2; GCF-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Purity/Purification
Caprylic acid and ammonium sulfate precipitation
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Molecular Weight
73,060 Da
OMIM
603256
3D Structure
ModBase 3D Structure for Q32MZ4
Immunogen
TRIP / LRRFIP1 antibody was raised against recombinant human Leucine-rich repeat flightless-interacting protein 1 protein.
Immunogen Description
Recombinant human Leucine-rich repeat flightless-interacting protein 1 protein.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-TRIP / LRRFIP1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes for anti-TRIP / LRRFIP1 antibody
IHC-P (10 ug/ml)

Immunohistochemistry - Paraffin (IHC) of anti-TRIP / LRRFIP1 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-TRIP / LRRFIP1 Polyclonal Antibody – Cat# MBS249951

Immunohistochemistry - Paraffin (IHC) of anti-TRIP / LRRFIP1 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-TRIP / LRRFIP1 Polyclonal Antibody, Immunohistochemistry - Paraffin (IHC) – Cat# MBS249951

Other Notes

Small volumes of anti-TRIP / LRRFIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIP / LRRFIP1 purchase

MBS249951 is an antibody targeting TRIP / LRRFIP1. Also known as Anti-TRIP / LRRFIP1 Antibody IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIP / LRRFIP1. It may not necessarily be applicable to this product.

NCBI GI #
212276070
NCBI GeneID
9208
NCBI Accession #
NP_004726.2
UniProt Primary Accession #
Q32MZ4
UniProt Secondary Accession #
O75766; O75799; Q32MZ5; Q53T49; Q6PKG2; Q9Y607; E9PGZ2
UniProt Related Accession #
Q32MZ4
GenBank Nucleotide #
NM_004735.3
NCBI Official Full Name
leucine-rich repeat flightless-interacting protein 1 isoform 4
NCBI Official Synonym Full Names
leucine rich repeat (in FLII) interacting protein 1
NCBI Official Symbol
LRRFIP1
NCBI Official Synonym Symbols
GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1
UniProt Protein Name
Leucine-rich repeat flightless-interacting protein 1
UniProt Synonym Protein Names
GC-binding factor 2; TAR RNA-interacting protein
UniProt Gene Name
LRRFIP1
UniProt Synonym Gene Names
GCF2; TRIP; LRR FLII-interacting protein 1
UniProt Entry Name
LRRF1_HUMAN
NCBI Protein Information
leucine-rich repeat flightless-interacting protein 1

UniProt Comments for TRIP / LRRFIP1

LRRFIP1: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; RNA-binding

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoplasm; cytoskeleton; cytosol; nucleus; plasma membrane

Molecular Function: DNA binding; double-stranded RNA binding; protein binding; protein homodimerization activity

Biological Process: innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of interferon type I production; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
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Research Articles on TRIP / LRRFIP1

1. Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/beta-catenin signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIP / LRRFIP1 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >5 publications with TRIP / LRRFIP1 and CTNNB1
 FLII antibody  >4 publications with TRIP / LRRFIP1 and FLII
 TNF antibody  >3 publications with TRIP / LRRFIP1 and TNF
 MYD88 antibody  >2 publications with TRIP / LRRFIP1 and MYD88

Pathways associated with anti-TRIP / LRRFIP1 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 FGFR1 Mutant Receptor Activation Pathway antibodies  FGFR1 Mutant Receptor Activation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway antibodies  LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR1 Fusion Mutants Pathway antibodies  Signaling By FGFR1 Fusion Mutants Pathway Diagram
 Signaling By FGFR1 In Disease Pathway antibodies  Signaling By FGFR1 In Disease Pathway Diagram

Diseases associated with anti-TRIP / LRRFIP1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with TRIP / LRRFIP1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with TRIP / LRRFIP1 and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with TRIP / LRRFIP1 and Nervous System Diseases
 Liver Diseases Antibodies  >3 publications with TRIP / LRRFIP1 and Liver Diseases
 Inflammation Antibodies  >3 publications with TRIP / LRRFIP1 and Inflammation
 Necrosis Antibodies  >3 publications with TRIP / LRRFIP1 and Necrosis
 Atherosclerosis Antibodies  >1 publications with TRIP / LRRFIP1 and Atherosclerosis
 Breast Neoplasms Antibodies  >1 publications with TRIP / LRRFIP1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with TRIP / LRRFIP1 and Neoplasms, Experimental
 Hyperplasia Antibodies  >1 publications with TRIP / LRRFIP1 and Hyperplasia

Organs/Tissues associated with anti-TRIP / LRRFIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with TRIP / LRRFIP1 and Blood
 Brain Antibodies  >5 publications with TRIP / LRRFIP1 and Brain
 Heart Antibodies  >5 publications with TRIP / LRRFIP1 and Heart
 Muscle Antibodies  >4 publications with TRIP / LRRFIP1 and Muscle
 Liver Antibodies  >3 publications with TRIP / LRRFIP1 and Liver
 Bone Antibodies  >2 publications with TRIP / LRRFIP1 and Bone
 Connective Tissue Antibodies  >1 publications with TRIP / LRRFIP1 and Connective Tissue
 Testis Antibodies  >1 publications with TRIP / LRRFIP1 and Testis
 Bone Marrow Antibodies  >1 publications with TRIP / LRRFIP1 and Bone Marrow
 Embryonic Tissue Antibodies  >1 publications with TRIP / LRRFIP1 and Embryonic Tissue
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