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CENPU Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249987

CENPU Antibody, CENP-U Antibody, CENP50 Antibody, CENPU50 Antibody, Centromere protein U Antibody, ICEN24 Antibody, KLIP1 Antibody, Polo-box-interacting protein 1 Antibody, MLF1-interacting protein Antibody, CENP-50 Antibody, Centromere protein of 50 kDa… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CENPU / MLF1IP, Polyclonal Antibody
Full Product Name
Anti-CENPU / MLF1IP Antibody IHC-plus
Product Gene Name
anti-CENPU antibody
Product Synonym Gene Name
MLF1IP
Product Synonym Names
Rabbit Polyclonal to Human CENPU / MLF1IP; Human CENPU / MLF1IP; CENP-U; CENP50; CENPU50; Centromere protein U; ICEN24; KLIP1; Polo-box-interacting protein 1; MLF1-interacting protein; CENP-50; Centromere protein of 50 kDa; MLF1 interacting protein; MLF1IP; PBIP1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7.2, 50% glycerol
Purity/Purification
Affinity purified
Concentration
1 mg/ml (lot specific)
Specificity
Human MLF1IP / CENP-U
Preparation and Storage
Store at -20 degree C.
Molecular Weight
38,102 Da
OMIM
611511
3D Structure
ModBase 3D Structure for Q71F23
Immunogen
CENPU / MLF1IP antibody was raised against recombinant Human full length CENP-50.
Immunogen Description
Recombinant Human full length CENP-50.
Immunogen Type
Recombinant protein
Target Species
Human
Applications Tested/Suitable for anti-CENPU antibody
Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)
Application Notes for anti-CENPU antibody
ICC (1:1000)
IHC-P (1:100)

Immunohistochemistry (IHC) of anti-CENPU antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-CENPU Polyclonal Antibody – Cat# MBS249987

Immunocytochemistry (ICC) of anti-CENPU antibody

 
Rabbit Anti-CENPU Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS249987

Other Notes

Small volumes of anti-CENPU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CENPU purchase

MBS249987 is an antibody targeting CENPU. Also known as Anti-CENPU / MLF1IP Antibody IHC-plus. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CENPU. It may not necessarily be applicable to this product.

NCBI GI #
38016935
NCBI GeneID
79682
NCBI Accession #
NP_078905.2
UniProt Primary Accession #
Q71F23
UniProt Secondary Accession #
Q09GN2; Q32Q71; Q9H5G1; A2RRD9
UniProt Related Accession #
Q71F23
GenBank Nucleotide #
NM_024629.3
NCBI Official Full Name
centromere protein U
NCBI Official Synonym Full Names
centromere protein U
NCBI Official Symbol
CENPU
NCBI Official Synonym Symbols
KLIP1; PBIP1; CENP50; MLF1IP; CENPU50
UniProt Protein Name
Centromere protein U
UniProt Synonym Protein Names
Centromere protein of 50 kDa; CENP-50; Interphase centromere complex protein 24; KSHV latent nuclear antigen-interacting protein 1; MLF1-interacting protein; Polo-box-interacting protein 1
Protein Family
Centromere protein
UniProt Gene Name
CENPU
UniProt Synonym Gene Names
ICEN24; KLIP1; MLF1IP; PBIP1; CENP-U; CENP-50
UniProt Entry Name
CENPU_HUMAN
NCBI Protein Information
centromere protein U

NCBI Summary for CENPU

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
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UniProt Comments for CENPU

CENPU: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: cytosol; microtubule organizing center; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: chordate embryonic development; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle; nucleosome assembly; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; transcription, DNA-dependent; viral reproduction
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Research Articles on CENPU

1. MLF1IP significantly promotes prostate cancer cell proliferation and colony formation and significantly inhibits apoptosis without affecting cell cycle phase arrest in prostate cancer cell lines

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CENPU antibody

 Reference Product  PubMed Publications
 CENPO antibody  >1 publications with CENPU and CENPO
 PLK1 antibody  >1 publications with CENPU and PLK1
 CENPP antibody  >1 publications with CENPU and CENPP

Pathways associated with anti-CENPU antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Nucleosome Assembly Pathway antibodies  Nucleosome Assembly Pathway Diagram
 PLK1 Signaling Events Pathway antibodies  PLK1 Signaling Events Pathway Diagram

Organs/Tissues associated with anti-CENPU antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with CENPU and Skin
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