MYO7A Antibody – Rabbit Polyclonal

MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Motor

Cellular Component: photoreceptor inner segment; microvillus; lysosomal membrane; cell; cytosol; stereocilium; cytoskeleton; photoreceptor outer segment; apical plasma membrane; cytoplasm; melanosome; synapse; intracellular; myosin complex; photoreceptor connecting cilium

Molecular Function: protein domain specific binding; protein homodimerization activity; motor activity; nucleotide binding; protein N-terminus binding; ADP binding; actin-dependent ATPase activity; actin binding; calmodulin binding; actin filament binding; microfilament motor activity; protein binding; spectrin binding; protein complex binding; ATP binding

Biological Process: mechanoreceptor differentiation; inner ear morphogenesis; actin filament-based movement; auditory receptor cell differentiation; phagocytosis; phagolysosome formation; intracellular protein transport; sensory perception of sound; pigment granule transport; cell projection organization and biogenesis; inner ear receptor cell differentiation; visual perception; transport; lysosome organization and biogenesis; sensory perception; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; inner ear development; post-embryonic organ morphogenesis; pigment granule localization