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SLC8A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2528975

This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types.… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SLC8A3, Polyclonal Antibody
Full Product Name
SLC8A3 Polyclonal Antibody
Product Gene Name
anti-SLC8A3 antibody
Product Synonym Names
NCX3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.8mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
102,804 Da
OMIM
607991
Immunogen
Synthetic peptide of human SLC8A3
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SLC8A3 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SLC8A3 antibody
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-SLC8A3 antibody

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SLC8A3 Polyclonal Antibody at dilution 1:50
Rabbit Anti-SLC8A3 Polyclonal Antibody – Cat# MBS2528975

Other Notes

Small volumes of anti-SLC8A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC8A3 purchase

MBS2528975 is an antibody targeting SLC8A3. Also known as SLC8A3 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC8A3. It may not necessarily be applicable to this product.

NCBI GI #
152012489
NCBI GeneID
6547
NCBI Accession #
AAI50194.1
UniProt Secondary Accession #
Q5K3P6; Q5K3P7; Q8IUE9; Q8IUF0; Q8NFI7; Q96QG1; Q96QG2
UniProt Related Accession #
P57103
NCBI Official Full Name
SLC8A3 protein, partial
NCBI Official Synonym Full Names
solute carrier family 8 (sodium/calcium exchanger), member 3
NCBI Official Symbol
SLC8A3
NCBI Official Synonym Symbols
NCX3
UniProt Protein Name
Sodium/calcium exchanger 3
UniProt Synonym Protein Names
Na(+)/Ca(2+)-exchange protein 3; Solute carrier family 8 member 3
Protein Family
Sodium/calcium exchanger
UniProt Gene Name
SLC8A3
UniProt Synonym Gene Names
NCX3
UniProt Entry Name
NAC3_HUMAN
NCBI Protein Information
sodium/calcium exchanger 3; Na(+)/Ca(2+)-exchange protein 3; Na+/Ca2+ exchanger 3; sodium/calcium exchanger SLC8A3; solute carrier family 8 (sodium-calcium exchanger), member 3; solute carrier family 8 member 3

NCBI Summary for SLC8A3

This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]
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UniProt Comments for SLC8A3

SLC8A3: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: microtubule; mitochondrion; cell soma; integral to membrane; dendritic spine; plasma membrane; sarcolemma

Molecular Function: calmodulin binding; calcium:sodium antiporter activity

Biological Process: telencephalon development; hemopoietic progenitor cell differentiation; ion transport; cell communication; blood coagulation; transmembrane transport
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Research Articles on SLC8A3

1. Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC8A3 antibody

 Reference Product  PubMed Publications
 GPHN antibody  >1 publications with SLC8A3 and GPHN

Pathways associated with anti-SLC8A3 antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Calcium Homeostasis Pathway antibodies  Platelet Calcium Homeostasis Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Reduction Of Cytosolic Ca++ Levels Pathway antibodies  Reduction Of Cytosolic Ca++ Levels Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram

Diseases associated with anti-SLC8A3 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >16 publications with SLC8A3 and Brain Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with SLC8A3 and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >2 publications with SLC8A3 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with SLC8A3 and Necrosis
 Neurologic Manifestations Antibodies  >2 publications with SLC8A3 and Neurologic Manifestations
 Heart Defects, Congenital Antibodies  >1 publications with SLC8A3 and Heart Defects, Congenital
 Hypertension Antibodies  >1 publications with SLC8A3 and Hypertension
 Fibrosis Antibodies  >1 publications with SLC8A3 and Fibrosis
 Memory Disorders Antibodies  >1 publications with SLC8A3 and Memory Disorders
 Learning Disorders Antibodies  >1 publications with SLC8A3 and Learning Disorders

Organs/Tissues associated with anti-SLC8A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36 publications with SLC8A3 and Brain
 Blood Antibodies  >6 publications with SLC8A3 and Blood
 Muscle Antibodies  >6 publications with SLC8A3 and Muscle
 Bone Antibodies  >3 publications with SLC8A3 and Bone
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