GLMN Antibody – Rabbit Polyclonal

GLMN: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Defects in GLMN are the cause of glomuvenous malformations (GVMs). GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 1p22.1

Cellular Component: Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; intracellular

Molecular Function: protein binding; hepatocyte growth factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase inhibitor activity

Biological Process: muscle cell differentiation; negative regulation of T cell proliferation; positive regulation of interleukin-2 biosynthetic process; neural tube closure; regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination; vasculogenesis; regulation of gene expression, epigenetic; positive regulation of phosphorylation; positive regulation of cytokine secretion

Disease: Glomuvenous Malformations