AK6 Antibody – Rabbit Polyclonal

This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TAFII31 iso2: a component of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is essential for mediating regulation of RNA polymerase transcription. TAFII31 binds to p53, the basal transcription factor GTF2B, and the acidic transactivator viral protein 16 (VP16). It is a coactivator for P53.

Protein type: Acetyltransferase; EC 2.7.4.3; Kinase, other; Transcription initiation complex; DNA-binding

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: nucleoplasm; PCAF complex; transcription factor TFIID complex

Molecular Function: ATPase binding; DNA binding; histone acetyltransferase activity; p53 binding; protein binding; protein heterodimerization activity; transcription activator binding; transcription coactivator activity

Biological Process: box C/D snoRNP assembly; establishment and/or maintenance of chromatin architecture; gene expression; negative regulation of apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; response to DNA damage stimulus; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction