2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer (Rp-2'-O-MB-cAMPS)

C₁₄H₁₇N₅O₆PS.Na; MW 437.4; lambda_max 258 nm; epsilon 15200; sodium salt; purity > 97% HPLC. Lipophilic precursor of Rp-cAMPS, a competitive inhibitor of protein kinase A. During metabolic activation by esterases the inhibitor and butyrate are released. Caution: Butyrate was shown to have distinct biological effects! Significantly more lipophilic and membrane-permeant compared to Rp-cAMPS. Resistant against mammalian phosphodiesterases. Detailed technical information and updated reference available for Rp-cAMPS on request. Reference: Vischer et al., Blood, 91, 118 - 127 (1998); Ouyang et al., Proc. Natl. Acad. Sci. USA, 105, 11993 - 11997 (2008).

Small volumes of 2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer (Rp-2'-O-MB-cAMPS) biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS256079 is a biochemical targeting 2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer (Rp-2'-O-MB-cAMPS).