RPS6KA2 Antibody – Rabbit Polyclonal

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RSK3: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; Tumor suppressor; Translation; Kinase, protein; AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; spindle; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; ATP binding

Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; heart development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; oocyte maturation; brain renin-angiotensin system; negative regulation of cell cycle; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cell proliferation; synaptic transmission; peptidyl-serine phosphorylation; heart contraction; negative regulation of meiosis; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway